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1.A.9.1.2
The nicotinic acetylcholine activated cation selective channel precursor, Acr-2 or Acr-3/Unc-38 (both β and α-type chains are required for activity; levamisole-gated; activity reduced by antagonists mecamylamine and d-tubocurarine) (Squire et al., 1995; Baylis et al., 1997). nAChR and TRPC channel proteins (1.A.4) mediate nicotine addiction in many animals from humans to worms (Feng et al., 2006). Functions at synapses in the nervous system and at neuromuscular junctions (Towers et al. 2006). Neonicottinoides affect worm behavior and development (Kudelska et al. 2017). C. elegans has a large number of nAcChR genes, only some of which are retained in parasitic nematodes (Holden-Dye et al. 2013). RIC-3 is an nAcChR chaparone (Treinin 2008).

Accession Number:Q93149
Protein Name:Acetylcholine receptor subunit beta-type acr-3
Length:487
Molecular Weight:56245.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate cation

Cross database links:

RefSeq: NP_509129.1   
Entrez Gene ID: 180937   
Pfam: PF02931    PF02932   
KEGG: cel:K11G12.7   

Gene Ontology

GO:0030054 C:cell junction
GO:0016021 C:integral to membrane
GO:0045211 C:postsynaptic membrane
GO:0004889 F:nicotinic acetylcholine-activated cation-se...
GO:0004872 F:receptor activity
GO:0006811 P:ion transport

References (2)

[1] “ACR-3, a Caenorhabditis elegans nicotinic acetylcholine receptor subunit. Molecular cloning and functional expression.”  Baylis H.A.et.al.   9606719
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MQKIWLFSII TIFLITELQC YPNSAEERLL SYIFDGYNSL IRPVLNASSP PIEVFFSLAF 
61:	VLLINVDEKN QIMQTNVWPT MKWNDYQMQW DPREFDGIKT IRVPPDKVWL PDIVLFNNAD 
121:	GNYLVSFYSN VVVEHTGDML WVPPAVYKSS CLIDVEFFPF DEQVCSLTFG SWTFRKDELQ 
181:	LSYLSGKRHV ELNDYLPSGV WDLIDAPGLL IDERSKISYQ IKIRRKALFY TVILIMPTVL 
241:	MAFLSMMVFY LPAESSEKIT LAISILLALV VFLLVVSKIL PPTSSTIPLM AKYLLMTFIM 
301:	NMITIMVSVI IINVYFRGPA THIMPNWVKT VFLKFLPVLF VMRRPESTEK ELAKMKREKR 
361:	ERRSMKSALK TFFKRNDAKI SEQPKQTSRK DGSSSEEKLS SDAKKAIEAI EYITTHLTHD 
421:	NAFKRQREEW KFVSVVIDRL LLYLFFAVTT GGTVGILLSA PNVFEQVNQT SVIERLKQQA 
481:	AEEMLNS