1.C.107.1.4
The trimeric Tc toxin complex consisting of three subunits, TcdA, TcdB
and TccC (TcA, B and C, respectively) of 2525, 1476 and 1043 aas, respectively.
Several 3-d structures and their modes of action and secretion have been
described (see the family description) (Gatsogiannis et al. 2013; Yang and Waterfield 2013; Moriya et al. 2017). Clostridioides difficile toxins TcdA and TcdB are inhibited by the amiodarone derivative dronedarone (Matylitsky et al. 2024).
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| Accession Number: | Q93EP6 |
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| Protein Name: | TcdB1 |
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| Length: | 1476 |
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| Molecular Weight: | 165139.00 |
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| Species: | Photorhabdus luminescens [29488] |
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| Substrate |
toxin |
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1: MQNSQTFSVT ELSLPKGGGA ITGMGEALTP AGPDGMAALS LPLPISAGRG YAPSLTLNYN
61: SGTGNSPFGL GWDCGVMAIR RRTSTGVPNY DETDTFLGPE GEVLVVALNE AGQADIRSES
121: SLQGINLGAT FTVTCYRSRL ESHFNRLEYW QPQTTGATDF WLIYSPDGQV HLLGKNPQAR
181: ISNPLNVNQT AQWLLEASIS SHSEQIYYQY RAEDEAGCET DELAAHPSAT VQRYLQTVHY
241: GNLTASDVFP TLNGDDPLKS GWMFCLVFDY GERKNSLSEM PLFKATGNWL CRKDRFSRYE
301: YGFELRTRRL CRQILMFHRL QTLSGQAKGD DEPALVSRLI LDYDENAMVS TLVSVRRVGH
361: EDNNTVTALP PLELAYQPFE PEQTALWQSM DVLANFNTIQ RWQLLDLKGE GVPGILYQDR
421: NGWWYRSAQR QAGEEMNAVT WGKMQLLPIT PAVQDNASLM DINGDGQLDW VITGPGLRGY
481: HSQHPDGSWT RFTPLHALPI EYSHPRAQLA DLMGAGLSDL VLIGPKSVRL YVNNRDGFTE
541: GRDVVQSGDI TLPLPGADAR KLVAFSDVLG SGQAHLVEVS ATQVTCWPNL GHGRFGQPIV
601: LPGFSQSAAS FNPDRVHLAD LDGSGPADLI YVHADRLDIF SNESGNGFAK PFTLSFPDGL
661: RFDDTCQLQV ADVQGLGVVS LILSVPHMAP HHWRCDLTNA KPWLLSETNN NMGANHTLHY
721: RSSVQFWLDE KAAALATGQT PVCYLPFPVH TLWQTETEDE ISGNKLVTTL RYAHGAWDGR
781: EREFRGFGYV EQTDSHQLAQ GNAPERTPPA LTKSWYATGL PAVDNALSAG YWRGDKQAFA
841: GFTPRFTLWK EGKDVPLTPE DDHNLYWLNR ALKGQPLRSE LYGLDGSAQQ QIPYTVTESR
901: PQVRQLQDGA TVSPVLWASV VESRSYHYER IISDPQCNQD ITLSSDLFGQ PLKQVSVQYP
961: RRNKPTTNPY PDTLPDTLFA SSYDDQQQLL RLTCRQSSWH HLIGNELRVL GLPDGTRSDA
1021: FTYDAKQVPV DGLNLETLCA ENSLIADDKP REYLNQQRTF YTDGKNQTPL KTPTRQALIA
1081: FTETAVLTES LLSAFDGGIT PDELPGILTQ AGYQQEPYLF PRTGENKVWV ARQGYTDYGT
1141: EAQFWRPVAQ RNSLLTGKMT LKWDTHYCVI TQTQDAAGLT VSANYDWRFL TPTQLTDIND
1201: NVHLITLDAL GRPVTQRFWG IESGVATGYS SSEEKPFSPP NDIDTAINLT GPLPVAQCLV
1261: YAPDSWMPLF SQETFNTLTQ EEQETLRDSR IITEDWRICA LTRRRWLQSQ KISTPLVKLL
1321: TNSIGLPPHN LTLTTDRYDR DSEQQIRQQV AFSDGFGRLL QASVRHEAGE AWQRNQDGSL
1381: VTKVENTKTR WAVTGRTEYD NKGQTIRTYQ PYFLNDWRYV SDDSARKEAY ADTHIYDPIG
1441: REIRVITAKG WLRQSQYFPW FTVSEDENDT AADALV