3.A.1.5.36
Peptide transporter encoded adjacent to the putative transport system with TC#3.A.1.5.35 (Akanuma et al. 2011). Induced by exogenous S-adenosylmethionine (SAM) at a concentration of 2muM which also enhanced antibiotic production and inhibited morphological development (Park et al. 2005). SAM can be imported into cells. Mutants in the bldK genes confer resistance to the toxic tripeptide, bialaphos (Nodwell et al. 1996).
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| Accession Number: | Q93IU3 |
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| Protein Name: | BldKA, putative ABC transport system integral membrane protein |
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| Length: | 343 |
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| Molecular Weight: | 37471.00 |
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| Species: | Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [100226] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
peptide |
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1: MTSPIEIEGA EASSVLDKES APQGDAPKPK EPEGRKPGQL MWARFKRDRA GVISAFVVLF
61: FFVIAAAAPL ISMVYGKDPY TLYGQDNPDL LDMFTMPAAP YGGIDGDFWF GIEPGLGRDV
121: FTQLLYGMRN SMATALAATI IMTVLGVLIG LAGGYFGGKI DYWLGRITDF FMALPSQLFF
181: VAAMPVITTV FVAPDKETPT YVRAAAIIIV LSFLGWMSMA RIVRGATMSL RDREFIEAAR
241: ISGASPWRIL RKELLPNIVT PTLVQATLTL PSTILSIAFL SFVGVGYVEP TPDWGRMFAI
301: GADIVEQDPY YMLFPGVAMV IFIVAFNLLG DSVRDAFDPK GNR