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2.A.1.8.11
The 24 TMS, 2 domain, NarK1-NarK2 porter (NarK1 = a NO3-/H+ symporter; NarK2 = a NO3-/NO2- antiporter).  NarK1 is a nitrate/proton symporter with high affinity for nitrate while NarK2 is a nitrate/nitrite antiporter with lower affinity for nitrate (Goddard et al., 2008).  Each transporter requires two conserved arginine residues for activity.  A transporter consisting of inactivated NarK1 fused to active NarK2 has a dramatically increased affinity for nitrate compared with NarK2 alone, implying a functional interaction between the two domains (Goddard et al., 2008).

Accession Number:Q93PW1
Protein Name:NarK
Length:905
Molecular Weight:98267.00
Species:Paracoccus pantotrophus (Thiosphaera pantotropha) [82367]
Number of TMSs:24
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate nitrite, nitrate

Cross database links:

Pfam: PF07690   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015103 F:inorganic anion transmembrane transporter a...
GO:0015698 P:inorganic anion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Maximal expression of membrane-bound nitrate reductase in Paracoccus is induced by nitrate via a third FNR-like regulator named NarR.”  Wood N.J.et.al.   11371524

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPDPSSFSPM QQQKALWLST TAFTLCFAVW TIFSIIGITI KEELGLTEFE YGVLIATPIL 
61:	TGSLVRLILG VWTERYGGRL VFSLQMLFTG LATWALTWAD SYAGFLLAAL GVGMAGGSFI 
121:	IGVAYVSKWF PAQRQGTALG IFGMGNVGAA VTKFIAPFIL VAWGWQAVAQ IWAVGIALMG 
181:	VVFLLVARDD PDFEARRAQG IAGPTLAEQF APLKKLQVWR FALYYFFVFG GFVALALWLP 
241:	HYLTQVYGVD LRVAGMAAAA FSLSASIFRA YGGILSDRFG ARTVMYWTFG FSALFLFMLS 
301:	YPPTDYTIRG KDGLISFSTE MGLWPFVVTL FALGFFMSLG KAAIFKHIPV YYPNHVGAVG 
361:	GLVGMIGGLG GFVLPIVFGA ALDLTGIWTS CFALLLLIVV VSMAWMHLSI RAMERRAQGR 
421:	ALDRLPNFPE LAEVHDPERT VMPRVLDDWR PENPTFWAEQ GRRIARRNLW ISIPALTLAF 
481:	AVWMVWSVVV AKLPLIGFGF TQDQLFWLAA LPALSGATVR IFYSFMVPIF GGRLWTTLST 
541:	ASLLIPAMGI GYAVQDPATP YVIFVALALL CGLGGANFAS SMANISFFFP KSEKGNALGL 
601:	NAGLGNLGVS LMQFLVPIVI TMGVFGAMGG AAQELSDGSR LWMQNAGFIW VPFIIASTIA 
661:	AWLGMNDITD ARASFREQAV IFTRLHNWVM CLLYIGTFGS FIGYSAGFPL LIKLAFPDVN 
721:	ALQFVFLGPL VGALSRAGTG WLSDRVGGGR VTFWVFAGMI ASVGLVIVSL QALSFWGFFA 
781:	GFMALFFFTG VGNSSTFQMI PVIMRKEVAR LEPQLSPEDR RRQSDRESAA IIAFTSAIGA 
841:	YGGFFIPKAY GSSIALTGSA IGALWAFLGF YVLCLAVTWV FYTRPGGLLH DIERGRASAG 
901:	AASPA