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3.D.4.11.1
Cytochrome oxidase (Cox or CcO).  Reversible hydration-level changes of the cavity can be a key factor that regulates the branching of proton transfer events and therefore contributes to the vectorial efficiency of proton transport (Son et al. 2017). Cox16 is required for the assembly of the mitochondrial cytochrome c oxidase (respiratory chain complex IV (CIV)), possibly by promoting the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2) (Cerqua et al. 2018; Aich et al. 2018). Lipid composition affects the efficiency of the functional reconstitution of the cytochrome c oxidase (Hugentobler et al. 2020). The DeepCys program has been used to predict the functions of cysteine residues in Cox2 (Nallapareddy et al. 2021).

Accession Number:Q96KJ9
Protein Name:CoxIV-2
Length:171
Molecular Weight:20010.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1
Substrate hydron

Cross database links:

RefSeq: NP_115998.2   
Entrez Gene ID: 84701   
Pfam: PF02936   
OMIM: 607976  gene
612714  phenotype
KEGG: hsa:84701   

Gene Ontology

GO:0005751 C:mitochondrial respiratory chain complex IV
GO:0004129 F:cytochrome-c oxidase activity
GO:0045333 P:cellular respiration
GO:0055114 P:oxidation reduction

References (4)

[1] “Mammalian subunit IV isoforms of cytochrome c oxidase.”  Huettemann M.et.al.   11311561
[2] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene.”  Shteyer E.et.al.   19268275

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLPRAAWSLV LRKGGGGRRG MHSSEGTTRG GGKMSPYTNC YAQRYYPMPE EPFCTELNAE 
61:	EQALKEKEKG SWTQLTHAEK VALYRLQFNE TFAEMNRRSN EWKTVMGCVF FFIGFAALVI 
121:	WWQRVYVFPP KPITLTDERK AQQLQRMLDM KVNPVQGLAS RWDYEKKQWK K