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3.A.1.14.14 The Fe³⁺ /Fe3⁺ferrichrome/Fe³⁺heme uptake porter; SiuABDG (FtsABCD) (Montañez et al., 2005; Hanks et al. 2005; Li et al. 2013). A similar system has been characterized in S. iniae (Wang et al. 2013).
Accession Number:	Q9A198
Protein Name:	Ferrichrome ABC transporter aka SiuD aka Spy0385
Length:	310
Molecular Weight:	34747.00
Species:	Streptococcus pyogenes serotype M1 [301447]
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	iron(3+)

RefSeq:	NP_268705.1 YP_281687.1
Entrez Gene ID:	3572574 900654
Pfam:	PF01497
BioCyc:	SPYO160490:SPY0385-MONOMER SPYO293653:M5005_SPY0323-MONOMER
Gene Ontology GO:0005381 F:iron ion transmembrane transporter activity GO:0006827 P:high-affinity iron ion transport
References (2) [1] “Complete genome sequence of an M1 strain of Streptococcus pyogenes.” Ferretti J.J.et.al. 11296296 [2] “Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.” Sumby P.et.al. 16088826

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MKKLTLLLTL CLTTITLIAC GNQATNHSNT ASKSLSPMPQ IAGVTYYGDI PKQPKRVVSL 
61:	ASTYTGYLKK LDMNLVGVTS YDKKNPILAK TVKKAKQVAA TDLEAVTTLK PDLIVVGSTE 
121:	ENIKQLAEIA PVISIEYRKR DYLQVLSDFG RIFNKEDKAK KWLKDWKTKT AAYEKEVKAV 
181:	TGDKATFTIM GLYEKDVYLF GKDWGRGGEI IHQAFHYDAP EKVKTEVFKQ GYLSLSQEVL 
241:	PDYIGDYVVV AAEDDKTGSA LYESKLWQSI PAVKKHHVIK VNANVFYFTD PLSLEYQLET 
301:	LREAILSSEN

3.A.1.14.14
The Fe³⁺ /Fe3⁺ferrichrome/Fe³⁺heme uptake porter; SiuABDG (FtsABCD) (Montañez et al., 2005; Hanks et al. 2005; Li et al. 2013). A similar system has been characterized in S. iniae (Wang et al. 2013).

Cross database links:

Gene Ontology

References (2)

External Searches:

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3.A.1.14.14The Fe3+ /Fe3+ferrichrome/Fe3+heme uptake porter; SiuABDG (FtsABCD) (Montañez et al., 2005; Hanks et al. 2005; Li et al. 2013). A similar system has been characterized in S. iniae (Wang et al. 2013).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

3.A.1.14.14
The Fe³⁺ /Fe3⁺ferrichrome/Fe³⁺heme uptake porter; SiuABDG (FtsABCD) (Montañez et al., 2005; Hanks et al. 2005; Li et al. 2013). A similar system has been characterized in S. iniae (Wang et al. 2013).