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3.A.1.135.2 The heterodimeric putative multidrug exporter, RscA/RscB; probably orthologous to YdaG/YbdA (TC #3.A.1.117.4) [Transcription is activated by stress conditions (heat, acid) and repressed by a 2-component system, CovRS (Dalton et al., 2006)]
Accession Number:	Q9A1K5
Protein Name:	RscA
Length:	568
Molecular Weight:	62978.00
Species:	Streptococcus pyogenes serotype M1 [301447]
Number of TMSs:	6
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	drug

RefSeq:	NP_268591.1 YP_281560.1
Entrez Gene ID:	3572702 900537
Pfam:	PF00664 PF00005
BioCyc:	SPYO160490:SPY0229-MONOMER SPYO293653:M5005_SPY0196-MONOMER
Gene Ontology GO:0016021 C:integral to membrane GO:0005524 F:ATP binding GO:0042626 F:ATPase activity, coupled to transmembrane m... GO:0055085 P:transmembrane transport
References (2) [1] “Complete genome sequence of an M1 strain of Streptococcus pyogenes.” Ferretti J.J.et.al. 11296296 [2] “Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events.” Sumby P.et.al. 16088826

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MLKDAILRYK WYALGSFFMV IGVVASSLLQ PHYLKSVLSA VIQNNQEKIY EVGKPLLIIA 
61:	LLGLMSGAIN TVLAAKIAQG VSADMREKTF RKIQDFSYAN IEAFNAGNLV VRLTNDINQI 
121:	QSLVMMMFQI LFRLPILFIG AFIMAVQTFP QLWWVIVVMV ILIALIMGLV MRQMGPRFGK 
181:	FQRLMDKINR IAKENLRGVR VVKSFVQEQQ QYTKFKETSN DLLALNLSIG YGFSLMQPAL 
241:	MLVSYLAVYV SINVVSTMVE TDPTVIGNIA SFMTYMMQIM FSIIVVGSMG MQVSRAFVSM 
301:	ARIRQILSTE PAMTFENEKE ETISGSIVFD DVSFTYPNDD EPTLKHISFA IEPGQMVGIV 
361:	GATGSGKSTL AQLIPRLFDP QDGQILLGGK PIKTLSQTTL RQSVSIVLQK AILFSGTIAD 
421:	NLRQGSAKAD IDAMQKAAQI AQAKEFIDRM DSRYESQVEE RGSNLSGGQK QRLSIARGVI 
481:	NHPKILILDD STSALDAKSE KRVQEALSHK LEGTTTVIVA QKISSVVKAD KILVLDQGQL 
541:	IGEGTHAELV ANNAIYREIY ETQKGREE

3.A.1.135.2
The heterodimeric putative multidrug exporter, RscA/RscB; probably orthologous to YdaG/YbdA (TC #3.A.1.117.4) [Transcription is activated by stress conditions (heat, acid) and repressed by a 2-component system, CovRS (Dalton et al., 2006)]

Cross database links:

Gene Ontology

References (2)

External Searches:

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3.A.1.135.2The heterodimeric putative multidrug exporter, RscA/RscB; probably orthologous to YdaG/YbdA (TC #3.A.1.117.4) [Transcription is activated by stress conditions (heat, acid) and repressed by a 2-component system, CovRS (Dalton et al., 2006)]

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

3.A.1.135.2
The heterodimeric putative multidrug exporter, RscA/RscB; probably orthologous to YdaG/YbdA (TC #3.A.1.117.4) [Transcription is activated by stress conditions (heat, acid) and repressed by a 2-component system, CovRS (Dalton et al., 2006)]