1.N.1.1.1
The Osteoclast fusion complex including DC-STAMP (470 aas; 7 TMSs), OC-STAMP (566 aas and 7 TMSs) and Leucocyte surface antigen, CD47 of 323 aas and 5 TMSs (Chiu et al. 2016; Møller et al. 2016; Zhang et al. 2014). CD47 is homologous to the first 5 TMSs of Presenilin-1 of Homo sapiens (1.A.54.1.1). It is therefore a presenilin homologue (unpublished observation). Sulforaphene (SFE) downregulates mRNA expression of DC-STAMP, OC-STAMP, and Atp6v0d2, which encode cell-cell fusion molecules (Takagi et al. 2017). SFE attenuates pre-osteoclast multinucleation via suppression of cell-cell fusion. ITIM on DC-STAMP is a functional motif that regulates osteoclast differentiation through the NFATc1/Ca2+ axis (Chiu et al. 2017).
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| Accession Number: | Q9BR26 |
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| Protein Name: | Osteoclast stimulatory transmembrane protein |
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| Length: | 566 |
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| Molecular Weight: | 61579.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
molecule |
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1: MPGHPGAAEQ LVKTGWRSWH LGFWKALAPL QAAWDAFSQP VPASCGQLLT QLLLCASLAA
61: AAAGLVYHWL ASLLLYPPGP SAMVATVCGL LVFLSLGLVP PVRCLFALSV PTLGMEQGRR
121: LLLSYSTATL AIAVVPNVLA NVGAAGQVLR CVTEGSLESL LNTTHQLHAA SRALGPTGQA
181: GSRGLTFEAQ DNGSAFYLHM LRVTQQVLED FSGLESLARA AALGTQRVVT GLFMLGLLVE
241: SAWYLHCYLT DLRFDNIYAT QQLTQRLAQA QATHLLAPPP TWLLQAAQLR LSQEELLSCL
301: LRLGLLALLL VATAVAVATD HVAFLLAQAT VDWAQKLPTV PITLTVKYDV AYTVLGFIPF
361: LFNQLAPESP FLSVHSSYQW ELRLTSARCP LLPARRPRAA APLAAGALQL LAGSTVLLEA
421: YARRLRHAIA ASFFTAQEAR RVRHLHARLQ RRHDRHQGQQ LPLGDPSCVP TPRPACKPPA
481: WIDYRLDALR TESSEGEGKE LWSCRDLSCN LGPVPPPCVT LGKSLHLSEP RFLHLHNDSI
541: FTIDVTYFPR RDVVRMEGNT GHDRPG