2.A.6.2.42
SmeDEF MDR efflux pump. Mediates resistance to a wide range of drugs including ethidium bromide and norfloxacin (Alonso and MartÃnez, 2000). Regulated by SmeT and activated by insertion of the transposon, IS1246 (Gould and Avison, 2006).
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| Accession Number: | Q9F240 |
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| Protein Name: | Putative RND protein |
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| Length: | 1040 |
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| Molecular Weight: | 111297.00 |
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| Species: | Stenotrophomonas maltophilia (Pseudomonas maltophilia) [40324] |
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| Number of TMSs: | 12 |
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| Substrate |
norfloxacin, ethidium bromide |
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1: MARFFIDRPI FAWVIAIIIM LAGGLALFKL PVSMYPNVAP PAVEISATYP GASAKVVEDS
61: VTQIIEQNMK GLDGLIYFSS NSSSNGQATI TLTFESGTNP DIAQVQVQNK LQLAMPLLPQ
121: EVQRQGINVA KSSSGFLNAI AFVSENGSMD ANDIADYVGS NVVDRLSRVP GVGNIQVFGG
181: KYAMRIWLDP NKLHTYGLSV PEVTAAIKAQ NAQVAIGQLG GAPSVKGQQL NATINAQSRL
241: QTPEQFRNII VRGAQDGAEL RLGDVARVEL GAESYDFVTR YNGQPASGLA VTLATGANAL
301: DTAAGVDAAL EDMKGFFPAG LKAEIPYDTT PFVRVSIKGV VQTLIEAIVL VFVVMYLFLQ
361: NFRATLIPTI AVPVVLLGTF GVLAMLGFSV NMLTMFAMVL AIGLLVDDAI VVVENVERIM
421: SEEGLSPLEA TRKSMGQITG ALVGIGLVLS AVFVPMAFMS GSTGVIYRQF SATIVSAMAL
481: SVLVAIVLTP ALCATMLKPL KKGEHHVAHR GLAGRFFNGF NRGFDRTSES YQRGVRGIIH
541: RPWRFMGIVA ALFVLMGVLF VRLPSSFLPN EDQGVLMALV QAPVGATQER TLESIAALEN
601: HFLQNEKDAV DSVFSVQGFS FAGMGQNAGM AFVKLKDWSE RDADNGVMPI TGRAMAALGQ
661: IKDAFIFAFP PPAIPELGTA SGYTFFLKDN SGQGHEALVA ARNQLLGLAA GSKKLANVRP
721: NGQEDTPQFR IDIDAAKATS LGLSIDQING TLAAAWGSSY IDDFVDRGRV KRVFVQADQA
781: FRMVPEDFDL WSVKNDKGEM VPFSAFATKH WDYGSPRLER YNGVSAMEIQ GEPAPGVASG
841: DAMAEIEQLA KQLPAGFGIE WTAMSYQERQ AGSQTPLLYT LSLMIVFLCL AAMYESWSVP
901: TAVLLAAPLG ILGAVLANTF KGLERDIYFQ VAMLTTVGLT SKNAILIVEF AKENLEKGAS
961: LIESIMHAVR DRLRPIVMTS LAFGMGVVPL AISTGAGSGA KQAIGTGVLG GMIVGTVLGV
1021: FFVPLFFVVV QRVFKRRSTT