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2.A.6.2.39
THe MuxABC-OpmB multidrug (aztreonam, macrolides, novobiocin and tetracycline) resistance efflux pump complex (with two RND-type proteins (MuxB and MuxC)), both required for activity (Mima et al., 2009).  Linking small antimicrobial peptides (AMPs) covalently to siderophores forms a new class of Trojan Horse antibiotics, with P1-DFP and P1-DFX being the most potent conjugates that kill P. aerugniosa (Olshvang et al. 2023).

Accession Number:Q9I0V5
Protein Name:Probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein
Length:426
Molecular Weight:45276.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate macrolide, aztreonam, novobiocin, tetracycline

Cross database links:

RefSeq: NP_251218.1   
Entrez Gene ID: 882937   
Pfam: PF00529   
BioCyc: PAER208964:PA2528-MONOMER   
KEGG: pae:PA2528   

Gene Ontology

GO:0016020 C:membrane
GO:0008565 F:protein transporter activity
GO:0051301 P:cell division
GO:0009306 P:protein secretion

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MTPTTGKSKF RTLRPWLITA LAFAAVIGLV MWLAAPASAP SSDGRPGRGG KPGAALPKAN 
61:	ALTVGVARVE QGDLALHFNA LGTVTAFNTV NVKPRVNGEL VKVLFQEGQE VKAGDLLAVV 
121:	DPRTYKAALA QAEGTLMQNQ AQLKNAEIDL QRYKGLYAED SIAKQTLDTQ EAQVRQLQGT 
181:	IRTNQGQVDD ARLNLTFTEV RAPISGRLGL RQVDIGNLVT SGDTTPLVVI TQVKPISVVF 
241:	SLPQQQIGTV VEQMNGPGKL TVTALDRNQD KVLAEGTLTT LDNQIDTTTG TVKLKARFEN 
301:	ADGKLFPNQF VNVRLLAQTL KGVLTIPANA VQRGTNGIYV YVVGADNKVS QRSVAIGTSE 
361:	NERVVVESGL KAGEQVVVEG TDRLRDGMEV RVAEASPQVL EGEPQKPQTG RPSGLQGDSV 
421:	GSGSAE