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3.A.1.109.4
The biofilm inducible ABC drug (tobramycin, gentamycin, and ciprofloxacin) resistance pump, PA1875-PA1877 (Zhang and Mah, 2008).  It is specifically induced and is most active when  growing in a biofilm.

Accession Number:Q9I2M0
Protein Name:PA1877
Length:395
Molecular Weight:44182.00
Species:Pseudomonas aeruginosa GN=PA1877 PE=4 SV=1 [287]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Tobramycin, Gentamycin, Ciprofloxacin

Cross database links:

HEGENOM: HBG433466
RefSeq: NP_250568.1   
Entrez Gene ID: 883045   
Pfam: PF00529   
BioCyc: PAER208964:PA1877-MONOMER   
KEGG: pae:PA1877   

Gene Ontology

GO:0009276 C:Gram-negative-bacterium-type cell wall
GO:0016021 C:integral to membrane
GO:0008565 F:protein transporter activity
GO:0009306 P:protein secretion

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MDSDRDAAAL RRQLADPLLA ATHPVYRPLL WTLLGCVLLF IGWAAWAQLD EVTRGDGRVV 
61:	PFSRIQKIQS LEGGILDRLL VKEGDLVEVG QPLVRLDETR FLTNFQESAN QASVLRAAIA 
121:	RLDAEVLGKK SIEFPPDVDP EGPLARSERE LFKSRRDKLV EGTQAIQRQI HLAQSQLDLV 
181:	RPLVAKRAVS QMEALKLSQD IATLSGKLTE LKSTYFQDAY TERAQRKADL SALEPIVQQR 
241:	QDQLRRTEIL SPVRGRVNTV LINTRGGVIQ PGEPIMEVIP VEERLLVEAK IKPRDVAFLV 
301:	PGMPAKVKIT AYDYTIYGDL KGTLEQISAD TIEEDTPHGK ESYYQVLIKT DGSQLKRGEE 
361:	VLPIIPGMVA EVDILSGKRS VLNYLLRPLI KARLY