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3.A.1.109.4
The biofilm inducible ABC drug (tobramycin, gentamycin, and ciprofloxacin) resistance pump, PA1875-PA1877 (Zhang and Mah, 2008).  It is specifically induced and is most active when  growing in a biofilm.

Accession Number:Q9I2M1
Protein Name:PA1876
Length:723
Molecular Weight:78231.00
Species:Pseudomonas aeruginosa GN=PA1876 PE=3 SV=1 [287]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Tobramycin, Gentamycin, Ciprofloxacin

Cross database links:

HEGENOM: HBG298315
RefSeq: NP_250567.1   
Entrez Gene ID: 882231   
Pfam: PF00664    PF00005   
BioCyc: PAER208964:PA1876-MONOMER   
KEGG: pae:PA1876   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005524 F:ATP binding
GO:0042626 F:ATPase activity, coupled to transmembrane m...
GO:0008233 F:peptidase activity
GO:0006508 P:proteolysis
GO:0055085 P:transmembrane transport

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MEAEKTPDNV VILNHDPIVD PLRQGLLLLC RQLGRPLGDA ELVDGMPLEH GRLPLHLVAR 
61:	ALRRADITAQ VTRQPLRRID RYLLPALLLL DDGRALVLVG NDGEHAEVLV PQSDGGSQRM 
121:	PLAELEALYS GTAVFAKCRY RPDGRVGDYA SALPEHWFFG PLKRLWRSYA EVTAAALVAN 
181:	VLAVASALFA MQVYDRVVPN AAFDTLWILA SGVALAIVLD GVLRIMRGHL LNVLGKRLDL 
241:	QLSTLLFSRV LSTRVAAKPA SMGAFSTQVR EFESVREFFT SSSAALISDL PFVAIFLLII 
301:	AVIGGHVVWV PLVACVLMIL PGLLTQRLLG HLSRQNLREG AMKNGVLLEA FEHLETVKAT 
361:	RAEGRCLHQW ETLTGELAGT AMKTHTLAST LSYSASIVQQ LCYVGVVVFG VYRISEGAMT 
421:	VGGLVACSIL ASRAIAPLSQ AAGILGRWQH TKVAMEGLDQ LMSAEQERPQ GKRFVHKERL 
481:	QGHYRLEGVR LAHGDSPPVV DVQALNIRAG ERVALLGGNG AGKSTLLRLL SGLLDAQAGR 
541:	LLLDDVSLTQ IDPADRQRGI GYLPQDVALF HGSLRDNLNL ENAALGDEEL LETLDGVGLG 
601:	AFVRGHPLGL DMPIQGNASL SGGQRQAVGL ARVLLQDPPI LLLDEPTAAF DQGSEKQVID 
661:	YLQQWLGKRT LVITTHKKSM LALVERAVVL RQGRVIMDGP LEQVVQGNQV QAPQAAEGGN 
721:	HGL