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3.A.1.109.4
The biofilm inducible ABC drug (tobramycin, gentamycin, and ciprofloxacin) resistance pump, PA1875-PA1877 (Zhang and Mah, 2008).  It is specifically induced and is most active when  growing in a biofilm.

Accession Number:Q9I2M2
Protein Name:PA1875
Length:425
Molecular Weight:47992.00
Species:Pseudomonas aeruginosa GN=PA1875 PE=4 SV=1 [287]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Tobramycin, Gentamycin, Ciprofloxacin

Cross database links:

HEGENOM: HBG638839
RefSeq: NP_250566.1   
Entrez Gene ID: 882209   
Pfam: PF02321   
BioCyc: PAER208964:PA1875-MONOMER   
KEGG: pae:PA1875   

Gene Ontology

GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MRGRRQYARK GRRHGKGAIW LLSLGLPMFA SAMPLDQAVR AGLAIHPEVR SAMAEADRAG 
61:	TEVEMAKGGY YPSVTMSGGP QEFDFGEIVY DLTASQMLYD WGRVTSKVDS ASATQRKLSE 
121:	AVLVARDDAA LDIVETYLDV LASERRVEAV REHIQRLDGI REMTQARGGD GYADRSELDR 
181:	ANLELSRAQE QLSLEKGNLQ DARNQYAILV GQEPADLVEP EPMSLQRYLA ASDMARVIRE 
241:	SPLQRKALED ANVAEAEVRE AKASLLPQLN LEASALRREI GGHPESDSVV SLRFRMDTFQ 
301:	GLSNFRRPTA AQQRLESAKW SADAMQRDIR RQLQNLFDNG DTLRWREQSL TQQVTESEQV 
361:	GELYREQFEV GRRDVIDLLN VQRERFEAER QLINLRIERK RIEYRAAAQV GLLGPLLENR 
421:	LNHGS