1.C.36.2.2
IIITCP protein complex, PopB/PopD. Purified PopB and PopD form pores in model membranes (Romano et al., 2011). PopB in isolation forms a biimodal distribution of two complexes with 6 and 12 subunits while PopD forms a hexameric complex. However when present together, they form a hexadecameric transmembrane complex (Romano et al. 2016). PopB assists with the proper insertion of PopD into cell membranes and is required for the formation of a functional translocon and host infection (Tang et al. 2018).
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| Accession Number: | Q9I323 |
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| Protein Name: | PopD |
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| Length: | 295 |
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| Molecular Weight: | 31309.00 |
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| Species: | Pseudomonas aeruginosa [287] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
protein |
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| RefSeq: |
NP_250400.1
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| Entrez Gene ID: |
879358
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| Pfam: |
PF05844
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| BioCyc: |
PAER208964:PA1709-MONOMER
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| KEGG: |
pae:PA1709
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[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.” Stover C.K. et.al. 10984043
[2] “Dissection of homologous translocon operons reveals a distinct role for YopD in type III secretion by Yersinia pseudotuberculosis.” Broms J.E. et.al. 12949185
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1: MIDTQYSLAA TQAAIPSEPI APGAAGRSVG TPQAAADLPQ VPAARADRVE LNAPRQVLDP
61: VRMEAAGSEL DSSVELLLIL FRIAQKAREL GVLQRDNENQ SIIHAQKAQV DEMRSGATLM
121: IAMAVIAGVG ALASAVVGSL GALKNGKAIS QEKTLQKNID GRNELIDAKM QALGKTSDED
181: RKIVGKVWAA DQVQDSVALR AAGRAFESRN GALQVANTVI QSFVQMANAS VQVRQGESQA
241: SAREGEVNAT IGQSQKQKVE DQMSFDAGFM KDVLQLIQQY TQSHNQAWRA AAGVV