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2.A.6.2.27
The Triclosan resistance efflux pump TriABC-OpmH (the only known RND pump requiring two MFPs) (Mima et al., 2007).  Triclosan (TCS), a persistent synthetic antimicrobial agent that is ubiquitous in aquatic environments, is notorious for its adverse health effects on organisms (Che et al. 2025). Molecular mechanisms of sublethal triclosan exposure in mosquitofish larvae (Gambusia affinis) have been studied.

Accession Number:Q9I6X6
Protein Name:TriA
Length:383
Molecular Weight:40362.00
Species:Pseudomonas aeruginosa [287]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell junction1 / Multi-pass membrane protein2
Substrate triclosan

Cross database links:

RefSeq: NP_248846.1   
Entrez Gene ID: 882149   
Pfam: PF00529   
BioCyc: PAER208964:PA0156-MONOMER   
KEGG: pae:PA0156   

Gene Ontology

GO:0016020 C:membrane
GO:0008565 F:protein transporter activity
GO:0051301 P:cell division
GO:0009306 P:protein secretion

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSDARGAFHS KGRWSRMALP AILCAGLLVG CGAEPPAEEH VRVLAQTVKM AEFASATSIT 
61:	GDIQARVQAD QSFRVGGKIV ERLVDVGDHV AAGQVLARLD PQDQRSNVEN AQAAVAAQQA 
121:	QSKLADLNYQ RQKALLPKGY TSQSEYDQAL ASVRSAQSSL KAAQAQLANA RDLLSYTELR 
181:	ASDAGVITAR QAEVGQVVQA TVPIFTLARD GERDAVFNVY ESLFSHDVDG QRITVSLLGK 
241:	PEVTASGKVR EITPTVDERS GTLKVKVGLD SVPAEMSLGS VVNASVAAPA EHSVVLPWSA 
301:	LSKVGEQPAV WLLDQQGKAR LQPVRVARYA SEKVVIDGGL EAGQTVVTVG GQLLHPGQVV 
361:	EVAQPPQPTQ STASRDAVGG GQP