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| Accession Number: | Q9K2S2 |
| Protein Name: | MrpA |
| Length: | 801 |
| Molecular Weight: | 89531.00 |
| Species: | Bacillus subtilis [1423] |
| Number of TMSs: | 21 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | sodium(1+), hydron |
Cross database links:
| Pfam: | PF00361 PF00662 |
|---|---|
| BioCyc: | SUBTI:BSU31600-MONOMER |
| KEGG: | bsu:BSU31600 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0015297
F:antiporter activity
GO:0015077
F:monovalent inorganic cation transmembrane t...
GO:0008137
F:NADH dehydrogenase (ubiquinone) activity
GO:0042773
P:ATP synthesis coupled electron transport
GO:0030004
P:cellular monovalent inorganic cation homeos...
GO:0015992
P:proton transport
GO:0006814
P:sodium ion transport
GO:0030435
P:sporulation resulting in formation of a cel...
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References (7)[1] “Analysis of the Bacillus subtilis genome: cloning and nucleotide sequence of a 62 kb region between 275 degrees (rrnB) and 284 degrees (pai).” Oudega B.et.al. 9274030 [2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.” Kunst F.et.al. 9384377 [3] “Analyses of a Bacillus subtilis homologue of the Na+/H+ antiporter gene which is important for pH homeostasis of alkaliphilic Bacillus sp. C-125.” Kosono S.et.al. 9878723 [4] “mrp, a multigene, multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasis.” Ito M.et.al. 10198001 [5] “Function of a principal Na(+)/H(+) antiporter, ShaA, is required for initiation of sporulation in Bacillus subtilis.” Kosono S.et.al. 10648512 [6] “Mrp-dependent Na(+)/H(+) antiporters of Bacillus exhibit characteristics that are unanticipated for completely secondary active transporters.” Ito M.et.al. 11356194 [7] “Catalytic properties of Staphylococcus aureus and Bacillus members of the secondary cation/proton antiporter-3 (Mrp) family are revealed by an optimized assay in an Escherichia coli host.” Swartz T.H.et.al. 17293423
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MQLLHLAILS PFLFAFIIPF LAKYAKRVHT GWFVLILPVL LFIYFLPMIR MTQSGETLRS 61: VLEWIPSLGI NFTVYIDGLG LLFALLITGI GSLVTLYSIF YLSKEKEQLG PFYVYLLMFM 121: GAMLGVVLVD NVMVLYMFWE LTSLSSFLLI GYWYKREKSR YGAAKSLLIT VSGGLCMLGG 181: FILLYLITDS FSIREMVHQV QLIAGHELFI PAMILILLGA FTKSAQFPFY IWLPDAMEAP 241: TPVSAYLHSA TMVKAGIYVI ARFSPIFAFS AQWFWIVSLV GLFTMVWGSF HAVKQTDLKS 301: ILAFSTVSQL GMIISMLGVS AAALHYGHTE YYTVAAMAAI FHLINHATFK GSLFMAVGII 361: DHETGTRDIR KLGGLMAIMP ITFTISLIGT FSMAGLPPFN GFLSKEMFFT SMLRVTHFDL 421: FNVQTWGVLF PLFAWIGSVF TFIYSMKLLF KTFRGNYQPE QLEKQAHEAP VGMLVPPVIL 481: VALAVSLFFF PNILSYSLIE PAMNSIYPTL LDGHEKFHVH ISQWHGVTTE LLMTAGIVVI 541: GTIGYLSLNK WKGIYKLFPS KLTLNRLYDK LLTMMEKGSY RVTKQYMTGF LRDYLLYIFA 601: GFIILIGGAF AIKGGFSFKT EGMAKIGVYE IILTLVMISA TVATVFARSR LTAIIALGVV 661: GYTLALFFVI FRAPDLALTQ LVIETISVAL FLLCFYHLPK LRLKTKTRTF RMTNFIISLG 721: VGVIVTLLGI ASSSQRTKDS IASFFVKHSH DLGGGDNVVN VILVDFRGFD TMFEITVLTI 781: AALGIYSMIK TKVKEEGKSG E