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3.A.1.12.6
Uptake system for hisitidine, proline, proline-betaine and glycine-betaine

Accession Number:Q9KKE2
Protein Name:HutW aka HISW
Length:285
Molecular Weight:30523.00
Species:Rhizobium meliloti (Sinorhizobium meliloti) [382]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Histidine, Proline, Proline betaine, Glycine betaine

Cross database links:

Pfam: PF00528   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “Characterization of a Snorhizobium meliloti ATP-binding cassette histidine transporter also involved in betaine and proline uptake.”  Boncompagni E.et.al.   10850986

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MFPDSLNLSI RAPVNDFIQA LVTNYGWVFK AISGVILKAV LFIEWILRGL PWWLVILAFM 
61:	ALACRSSRRW SLTLAVCALL ETVGVLGIWD LTMQTLALML MATIVSVVIG VPMGILVAKS 
121:	RVVRNITLPV LDVMQTMPSF VYLIPALMLF GLGKVPAILA TIIYAVPPLI RLTDLGIRQV 
181:	DAEVVEAATA FGGSPGQILF GVELPLATPT IMAGLNQTIM MALSMVVVAS MIGARGLGEQ 
241:	VLNGIQTLDV GKGLEAGIGI VILAVVLDRI TQGFGKPRTE DARNG