1.C.131.1.1
A secreted lipid binding protein of 1085 aas and 5 - 6 TMSs, VasX. Essential for killing of Dictyostelium discoideum (Miyata et al. 2011). It is a pore-forming toxin (Durand et al. 2014). It is a T6SS effector and may have a structure resembling that of Colicin Ia (Russell et al. 2014). VasW (295 aas, possibly with a C-terminal TMS) is an accessory protein for VasX (Miyata et al. 2013). The TsiV2 immunity protein (242 aas and 3 or 4 TMSs) protects against VasX. Its gene is adjacent to the vasX gene, and its promoter is within the vasX gene, clearly suggesting a common functional role to counteract the function of VasX (Miyata et al. 2013).
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| Accession Number: | Q9KNE4 |
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| Protein Name: | Immunity protein TsiV2 |
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| Length: | 242 |
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| Molecular Weight: | 27881.00 |
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| Species: | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [243277] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Host membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MLIDKNELEQ LKVKLHSSEV IYQWDSVAYG ERRSEIFRVF GAISAGIVPL WPFIFFADIQ
61: FNSKEFWGFI CFSLAGMAAA RYLFMPDHRY CYSLTQAGIY YTDQEVIPDA AYTFVRGFAW
121: VGIAVCLLAL AVVGPLAFVG AGGFALLAFG LTNFHPTVHK KEVYFADQLI VFDPIKEKMV
181: DLNTDSTDEP WFDRRLFFSS LDEKTHFIEL VKSIHNNVDY LPLQRVNDQY KHPIFNQELK
241: EE