1.C.131.1.1
A secreted lipid binding protein of 1085 aas and 5 - 6 TMSs, VasX. Essential for killing of Dictyostelium discoideum (Miyata et al. 2011). It is a pore-forming toxin (Durand et al. 2014). It is a T6SS effector and may have a structure resembling that of Colicin Ia (Russell et al. 2014). VasW (295 aas, possibly with a C-terminal TMS) is an accessory protein for VasX (Miyata et al. 2013). The TsiV2 immunity protein (242 aas and 3 or 4 TMSs) protects against VasX. Its gene is adjacent to the vasX gene, and its promoter is within the vasX gene, clearly suggesting a common functional role to counteract the function of VasX (Miyata et al. 2013).
|
| Accession Number: | Q9KNE5 |
|---|
| Protein Name: | Uncharacterized protein |
|---|
| Length: | 1085 |
|---|
| Molecular Weight: | 121043.00 |
|---|
| Species: | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [243277] |
|---|
| Number of TMSs: | 4 |
|---|
| Substrate |
|
|---|
1: MSNPNQAAKT GQTNDAQNPA SACPFKQPLI GIIPVRYAFD VYDDQGQALH PLPKADRQWK
61: GQFSIKQRSY TLRQLRDGWL YVYDETAKTL HEYEVVGCKL TKIDWSDDEA NKPTHERGSK
121: GESKSCLLYP AQHTLSIGYA HQRWTWRVCE HMRSNTSSRH AVMRKVSLKQ FESNGTHPHA
181: HFAQYLEDYV ADIGTPAEQD IFKDTCTPSL PVEKSEEAVK GTEFKFVADK AVVSSSDYLQ
241: DLPEQNCGLF VALNDPLADV SDLFVTFTTQ VAKRTKAIGD ETQQHKMQMA ELTRTLGRIR
301: LEEKEIPDFV KQDPIRILEL ERAITEYCAT AKLAEIESHH LASEGHSPSG NYALMQQQAE
361: QKLAELKTLY RFEPTSAQMR KWRKKDNSFI DEVRWADLDN FLVEHYTELK GLDEQIKQHY
421: AQFMSAFNQL GLDPLLFGMD NQDEVQQAYL LALTSQFLVV VTQVNHDEKS LEILKKDLSF
481: DSPKNLMALA STGFSLQANQ AINNHIQGFS TAFLSTSNPS DMVAFATAIA NWDTFTGDER
541: IQEKAWFKRW IEPAQSSFGA LQKAVANQAK ESWQAVMELL FPYQNQPKGG TPSLLANLRL
601: LLVESLVREE AVLQHNPKYA AELKQFETKL NAILQEMNDA LELKPGNVSP KNHQIATAQS
661: AQRKLGQLLS SELPMMLTLK NQAAMNTFQQ SVNEKLSALS KNVKTSSASV SQKLGGLGGL
721: LFALNLWNTM TVLENIRYKV AQYPSWNPFK NPALGEAIYA TGNTIVVAGA ISAGRAWVTI
781: AEQGLLDRTL KNALNTTKVL GTKDALKTFA KSIALVATVG MIASALETWE SWGKFNDSSK
841: TDLERFGYLL KAGATGAQGI IFYIQFFTLL GSGIGGPSIA AISAGWMLAG FAVIGIVYLI
901: GVILTNVFKR SELEIWLSKS TWGKESAHWP VGKELTELEH LLHRPSLRLS QVTQRKAAQW
961: MDSGSLQWQL ELTLPDYLKG QTIGLQITRL PAQPAYYQPQ REAVTPILIN EQQGKWSIED
1021: NQPVYRITLG GSEKDTVGVC VALPLRWGKE LSLKFYASGT RAGELDLQSA EANDIATRNL
1081: VVGKG