1.C.131.1.1 A secreted lipid binding protein of 1085 aas and 5 - 6 TMSs, VasX. Essential for killing of Dictyostelium discoideum (Miyata et al. 2011). It is a pore-forming toxin (Durand et al. 2014). It is a T6SS effector and may have a structure resembling that of Colicin Ia (Russell et al. 2014). VasW (295 aas, possibly with a C-terminal TMS) is an accessory protein for VasX (Miyata et al. 2013). The TsiV2 immunity protein (242 aas and 3 or 4 TMSs) protects against VasX. Its gene is adjacent to the vasX gene, and its promoter is within the vasX gene, clearly suggesting a common functional role to counteract the function of VasX (Miyata et al. 2013).
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Accession Number: | Q9KNE6 |
Protein Name: | Accessory protein VasW |
Length: | 295 |
Molecular Weight: | 34214.00 |
Species: | Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [243277] |
Substrate |
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1: MRSTNSFVVH NWVSLVPEME MDTQERLYLL VDGAQISHLA QALYRLSGEL VLEPLYLFPP
61: FEQLKEVSPY LVLATDTVKT WFLEQNQGLA GFFFASLDSI EEIAEQLRRL IQVESPYGST
121: VFLKMANSEC AYVLLSTQCQ PLWKVINRAW LPTRQGWQYV QRPELTATQD TPVRFKLTDE
181: QWQRLGNITW LNTLETVERH VQQWFPDLAQ QWQSDPELFH RHAQWAYQQG FSSERDLMLF
241: FNVLGFLGVD ALEKGKYPEI DPLLHQASSR TPSQRIEAAA ELAYQHSQSS QEVQG