1.A.9.1.13 Neuronal acetylcholine receptor with two subunits, α- and β-subunits, Unc-63 (Lev7; 502 aas) and Acr-2 (575 aas), respectively. Probably acts in cholinergic motoneurons to
regulate presynaptic neurotransmitter release, thereby ensuring normal
level of excitation of cholinergic motoneurons during locomotion
(Jospin et al. 2009). Involved in nAChR sensitivity to nicotine and levamisole (Culetto et al. 2004; Gottschalk et al. 2005). The AcChR subunits in C. elegans have been compared with those of parasitic nematodes (Holden-Dye et al. 2013). The Ascaris suum nicotinic acetylcholine receptor (nAChR) is modulated by compounds GSK575594A, diazepam and flumazenil (Stevanovic et al. 2021).
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Accession Number: | Q9N587 |
Protein Name: | Acetylcholine receptor subunit alpha-type unc-63 |
Length: | 502 |
Molecular Weight: | 57391.00 |
Species: | Caenorhabditis elegans [6239] |
Number of TMSs: | 4 |
Location1 / Topology2 / Orientation3: |
Cell junction1 / Multi-pass membrane protein2 |
Substrate |
cation |
---|
1: MGPNDHGFAY ILIFLLLSPP THANRDANRL FEDLIADYNK LVRPVSENGE TLVVTFKLKL
61: SQLLDVHEKN QIMTTNVWLQ HSWMDYKLRW DPVEYGGVEV LYVPSDTIWL PDVVLYNNAD
121: GNYQVTIMTK AKLTYNGTVE WAPPAIYKSM CQIDVEFFPF DRQQCEMKFG SWTYGGLEVD
181: LQHRDKHLEK EIEEDVEGVD GPTKEIVWVV DRGIDLSDYY PSVEWDILNV PGKRHSKRYP
241: CCESPFIDIT YEIHLRRKTL FYTVNLIFPS VGISFLTALV FYLPSDGGEK ISLCISILIS
301: LTVFFLLLVE IIPSTSLVIP LIGKYLLFTM VLVTLSVVVT VVTLNVHYRS PTTHTMPKWM
361: KRLFVDFLPK YLLMTRPQPP GHHSKPNRKF DSRASTFSIG VNHVLGQNSE LLSPGLNSNR
421: EESSFTLPRD NSPVRSAVES VAYIADHLKN EEDDKQVIED WKYISVVMDR IFLITFTFAC
481: AFGTVVIIAR APSIYDNTPA LA