TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.R.1.1.1
Membrane Contact Site (MCS).  Functions include lipid and ion transport between organelles as well as organelle positioning and division (Wu et al. 2018).
Constituents include:
Seipin, 398 aas and 2 - 4 TMSs, Q96G97.
Protrudin, 411 aas and 4 - 5 TMSs, Q5T4F4.
Spastin (SPAST, ADPSP, FSP2, SPG4), 616 aas, 1 N-terminal TMS, Q9UBP0.
Vesicle-associated membrane protein-associated protein A, (VAPA, VAP33), 249 aas, 1 C-terninal TMS, a member of TC family 9.B.17), Q9P0L0.
Vesicle-associated membane protein associated, VAPB/C (see TC 9.B.17.1.1), 243 aas and 1 C-terminal TMS, O95292.
Dynamin 2 (Dyn2, Dnm2) GTPase, 870 aas, 1 TMS, see TC# 8.A.34.1.4, P50570.
Mitofusin 2 (Mfn2, CPRP1) GTPase, 757 aas, 0 - 2 TMSs, (see TC# 1.N.6.1.2), O95140.
Acyl-CoA binding domain-containing protein 5, ACBD5, 534 aas, 1 C-terminal TMS, Q5T8D3.
Mitofusin; Its heptad repeat domain 1 has membrane destabilization function in mitochondrial fusion (Daste et al. 2018).
PDZ domain-containing protein 8,
PDZD8, of 1154 aas, a molecular tethering protein that connects ER and mitochondria membranes and is a shared component of at least two distinct MCSs (Hirabayashi et al. 2017; Elbaz-Alon et al. 2020).

Accession Number:Q9P0L0
Protein Name:Vesicle-associated membrane protein-associated protein A
Length:249
Molecular Weight:27893.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Single-pass type IV membrane protein2
Substrate

Cross database links:

Structure:
2RR3     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MASASGAMAK HEQILVLDPP TDLKFKGPFT DVVTTNLKLR NPSDRKVCFK VKTTAPRRYC 
61:	VRPNSGIIDP GSTVTVSVML QPFDYDPNEK SKHKFMVQTI FAPPNTSDME AVWKEAKPDE 
121:	LMDSKLRCVF EMPNENDKLN DMEPSKAVPL NASKQDGPMP KPHSVSLNDT ETRKLMEECK 
181:	RLQGEMMKLS EENRHLRDEG LRLRKVAHSD KPGSTSTASF RDNVTSPLPS LLVVIAAIFI 
241:	GFFLGKFIL