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3.A.2.2.5
H -translocating V-type ATPase (Dettmer et al., 2006). The mung bean (Phaseolus aureus) subunits a and c (c' and c") alone catalyzes passive channel-mediated proton flux, but the a,c,d complex does not (Ouyang et al., 2008).  A 4 TMS c-subunit of Tamarix hispida (onion), almost identical to the c-subunit of the A. thaliana homologue, plays a stress tolerance role in response to salt, drought, UV, oxidation, heat, cold, and heavy metals (Gao et al. 2011). The VHA-H subunit is up-regluated upon high salt stress conditions (Yang et al. 2018). The VHAc`1 protein seems to play an important role in plant stress tolerance (Wang et al. 2020).

Accession Number:Q9SDS7
Protein Name:V-type proton ATPase subunit C
Length:375
Molecular Weight:42619.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Peripheral membrane protein2
Substrate hydron

Cross database links:

Entrez Gene ID: 837840   
Pfam: PF03223   
KEGG: ath:AT1G12840   

Gene Ontology

GO:0009507 C:chloroplast
GO:0000325 C:plant-type vacuole
GO:0005886 C:plasma membrane
GO:0000221 C:vacuolar proton-transporting V-type ATPase, V1 domain
GO:0046961 F:proton-transporting ATPase activity, rotational mechanism
GO:0015986 P:ATP synthesis coupled proton transport
GO:0009809 P:lignin biosynthetic process
GO:0043255 P:regulation of carbohydrate biosynthetic process
GO:0009826 P:unidimensional cell growth

References (5)

[1] “The Arabidopsis det3 mutant reveals a central role for the vacuolar H(+)-ATPase in plant growth and development.”  Schumacher K.et.al.   10617574
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “A simple nomenclature for a complex proton pump: VHA genes encode the vacuolar H(+)-ATPase.”  Sze H.et.al.   11950611
[5] “A WNK kinase binds and phosphorylates V-ATPase subunit C.”  Hong-Hermesdorf A.et.al.   16427632

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MTSRYWVVSL PVKDSASSLW NRLQEQISKH SFDTPVYRFN IPNLRVGTLD SLLALGDDLL 
61:	KSNSFVEGVS QKIRRQIEEL ERISGVESNA LTVDGVPVDS YLTRFVWDEA KYPTMSPLKE 
121:	VVDNIQSQVA KIEDDLKVRV AEYNNIRGQL NAINRKQSGS LAVRDLSNLV KPEDIVESEH 
181:	LVTLLAVVPK YSQKDWLACY ETLTDYVVPR SSKKLFEDNE YALYTVTLFT RVADNFRIAA 
241:	REKGFQVRDF EQSVEAQETR KQELAKLVQD QESLRSSLLQ WCYTSYGEVF SSWMHFCAVR 
301:	TFAESIMRYG LPPAFLACVL SPAVKSEKKV RSILERLCDS TNSLYWKSEE DAGAMAGLAG 
361:	DSETHPYVSF TINLA