3.A.1.209.3
Haf-4/Haf-9 heterodimeric half transporter of 787 aas and 815 aas, respectively. Probably tranports antigenic peptides. Both proteins localize to the membrane of nonacidic, lysosome-associated, membrane
protein homologue (LMP-1)-positive intestinal granules from larval to
adult stages. Mutants of haf-4 and haf-9 exhibited granular defects in late larval and young adult intestinal
cells, associated with decreased brood size, prolonged defecation cycle,
and slow growth (Kawai et al. 2009). Thus they may mediate intestinal granular formation. HAF-4-HAF-9 heterodimer formation is required for their stabilization (Tanji et al. 2013). The HAF-4- and HAF-9-localizing organelles are distinct intestinal organelles associated with the endocytic pathway (Tanji et al. 2016; Tanji et al. 2017).
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| Accession Number: | Q9TZD9 |
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| Protein Name: | HAlF transporter (PGP related) |
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| Length: | 787 |
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| Molecular Weight: | 88276.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 9 |
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| Substrate |
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1: MNSTVASRFS WGLILASIDF LACLLFACLH DGTFKFANFT SQFGDFSFFT STIDLFLLQF
61: FRFALWMVPA AIHVANKADT LTMWKEPIFC SALLICAASP TKLLLLTEKL KPDEFLTFGD
121: TAFLVWNFIS AIILNSSWTR YFSRTPSSYI ILEDEDLEVA PKQTFELIFR LLQYCKREWL
181: WHISGFSWLF IYSITRIFVP YYTGQVIATV VATKSYPALS NAVYIMTIIS LVSAVAAGFR
241: GGSFEYAYAR IQRAIRYDLF HGLVKQDVAF YDAHKTGEVT SRLAADCQTM SDTVALNVNV
301: FLRNCVMLLG SMIFMMKLSW RLSLVTFILV PIIFVASKIF GTYYDLLSER TQDTIAESND
361: VAEEVLSTMR TVRSFSCENV EADRFYGKLT HTLDVTRTKA IAYIGFLWVS ELFQSFIIVS
421: VLWYGGHLVL TQKMKGDLLV SFLLYQMQLG DNLRQMGEVW TGLMQSVGAS RKVFEYIDRE
481: PQIQHNGEYM PENVVGKIEF RNVHFSYPTR SDQPILKDLS FTVEPGETVA LVGPSGSGKS
541: SCISLLENFY VPNAGQVLVD GVPLEEFEHH YIHKKIALVG QEPVLFARSV MENVRYGVEV
601: ADTEIIRSCE MANAHGFIMQ TTLKYETNVG EKGTQMSGGQ KQRIAIARAL VREPAILLLD
661: EATSALDTES EHLVQEAIYK NLDGKSVILI AHRLSTVEKA DKIVVINKGR VEQIGNHETL
721: LKDTNGTYAK LVQRQMMGDQ KPRKRPAVAR SGPQPAASIN VAGPSQGNAM SLLSTSFSQS
781: ASSVTSH