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2.A.3.8.18
Cystine/glutamate antiporter (Amino acid transport system xCT) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11).  The pathology and development of non-competive diaryl-isoxazole inhibitors have been presented (Newell et al. 2013).  In Lama paco (alpaca), the Slc7a11 porter of 503 aas and 12 TMSs probably functions in melanogenesis and coat color regulation (Tian et al. 2015).  It interacts with mucin-1 (MUC1-C; P15941) which forms a complex with xCT. It also forms a complex with SLC3A2 heavy chain (CD98hc, 4F2hc or MDU1 (TC# 8.A.9.2.2). Together they maintain glutathione levels and redox balance and influence cancer development (Hasegawa et al. 2016). xCT is the receptor for Kaposi's sarcoma-associated herpesvirus (KSHV, human herpesvirus 8), the causative agent of Kaposi's sarcoma and other lymphoproliferative syndromes often associated with HIV/AIDS (Kaleeba and Berger 2006). Sulfasalazine is an inhibitor of xCT that is known to increase cellular oxidative stress, giving it anti-tumor potential, but it seems to have many side effects (Nagane et al. 2018). xCT is a cancer stem cell-related target and can be used to develop preclinical therapeutic approaches, able to hamper tumor growth and dissemination (Ruiu et al. 2019). Residues involved in substrate binding have been proposed based on in silico approaches (Sharma and Anirudh 2019). The tissue distribution of xCT in chickens has been determined (Choi et al. 2020). xCT supports tumor cell growth through glutathione-based oxidative stress resistance, and mutations can enhance its stability (Oda et al. 2020). Signals of pseudo-starvation unveiled that SLC7A11 is key determinant in the control of Treg (T) cell proliferative potential (Procaccini et al. 2021). xCT antiporter function inhibits HIV-1 infection (Rabinowitz et al. 2021).

Accession Number:Q9UPY5
Protein Name:Cystine/glutamate transporter
Length:501
Molecular Weight:55423.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate cystine, glutamate(2-)

Cross database links:

Entrez Gene ID: 23657   
KEGG: hsa:23657   

Gene Ontology

GO:0005856 C:cytoskeleton
GO:0016021 C:integral to membrane
GO:0005792 C:microsome
GO:0005886 C:plasma membrane
GO:0005791 C:rough endoplasmic reticulum
GO:0015327 F:cystine:glutamate antiporter activity
GO:0007596 P:blood coagulation
GO:0007420 P:brain development
GO:0070306 P:lens fiber cell differentiation
GO:0050900 P:leukocyte migration
GO:0035094 P:response to nicotine
GO:0006979 P:response to oxidative stress
GO:0009636 P:response to toxin

References (7)

[1] “Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-.”  Sato H.et.al.   11213471
[2] “Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells.”  Bridges C.C.et.al.   11133847
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility.”  Gasol E.et.al.   15151999
[5] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983
[6] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[7] “Large-scale proteomics analysis of the human kinome.”  Oppermann F.S.et.al.   19369195

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FASTA formatted sequence
1:	MVRKPVVSTI SKGGYLQGNV NGRLPSLGNK EPPGQEKVQL KRKVTLLRGV SIIIGTIIGA 
61:	GIFISPKGVL QNTGSVGMSL TIWTVCGVLS LFGALSYAEL GTTIKKSGGH YTYILEVFGP 
121:	LPAFVRVWVE LLIIRPAATA VISLAFGRYI LEPFFIQCEI PELAIKLITA VGITVVMVLN 
181:	SMSVSWSARI QIFLTFCKLT AILIIIVPGV MQLIKGQTQN FKDAFSGRDS SITRLPLAFY 
241:	YGMYAYAGWF YLNFVTEEVE NPEKTIPLAI CISMAIVTIG YVLTNVAYFT TINAEELLLS 
301:	NAVAVTFSER LLGNFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH LPEILSMIHV 
361:	RKHTPLPAVI VLHPLTMIML FSGDLDSLLN FLSFARWLFI GLAVAGLIYL RYKCPDMHRP 
421:	FKVPLFIPAL FSFTCLFMVA LSLYSDPFST GIGFVITLTG VPAYYLFIIW DKKPRWFRIM 
481:	SEKITRTLQI ILEVVPEEDK L