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2.A.3.8.5 Cystine/glutamate antiporter, xCT (requires the 4F2hc protein (TC #8.A.9.2.1)). Functions in the generation of glutathione and plays a role in the oxidative stress response (Wang et al. 2015).
Accession Number:	Q9WTR6
Protein Name:	xCT aka SLC7A11
Length:	502
Molecular Weight:	55456.00
Species:	Mus musculus (Mouse) [10090]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	cystine, glutamate(2-)

RefSeq:	NP_036120.1
Entrez Gene ID:	26570
Pfam:	PF00324
KEGG:	mmu:26570
Gene Ontology GO:0016021 C:integral to membrane GO:0015171 F:amino acid transmembrane transporter activity GO:0006865 P:amino acid transport GO:0055085 P:transmembrane transport
References (3) [1] “Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins.” Sato H.et.al. 10206947 [2] “Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression.” Sasaki H.et.al. 12235164 [3] “The phagosomal proteome in interferon-gamma-activated macrophages.” Trost M.et.al. 19144319

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MVRKPVVATI SKGGYLQGNM SGRLPSMGDQ EPPGQEKVVL KKKITLLRGV SIIIGTVIGS 
61:	GIFISPKGIL QNTGSVGMSL VFWSACGVLS LFGALSYAEL GTSIKKSGGH YTYILEVFGP 
121:	LLAFVRVWVE LLVIRPGATA VISLAFGRYI LEPFFIQCEI PELAIKLVTA VGITVVMVLN 
181:	STSVSWSARI QIFLTFCKLT AILIIIVPGV IQLIKGQTHH FKDAFSGRDT SLMGLPLAFY 
241:	YGMYAYAGWF YLNFITEEVD NPEKTIPLAI CISMAIITVG YVLTNVAYFT TISAEELLQS 
301:	SAVAVTFSER LLGKFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH LPEILSMIHV 
361:	HKHTPLPAVI VLHPLTMVML FSGDLYSLLN FLSFARWLFM GLAVAGLIYL RYKRPDMHRP 
421:	FKVPLFIPAL FSFTCLFMVV LSLYSDPFST GVGFLITLTG VPAYYLFIVW DKKPKWFRRL 
481:	SDRITRTLQI ILEVVPEDSK EL

2.A.3.8.5
Cystine/glutamate antiporter, xCT (requires the 4F2hc protein (TC #8.A.9.2.1)). Functions in the generation of glutathione and plays a role in the oxidative stress response (Wang et al. 2015).

Cross database links:

Gene Ontology

References (3)

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2.A.3.8.5Cystine/glutamate antiporter, xCT (requires the 4F2hc protein (TC #8.A.9.2.1)). Functions in the generation of glutathione and plays a role in the oxidative stress response (Wang et al. 2015).

Cross database links:

Gene Ontology

References (3)

External Searches:

Analyze:

2.A.3.8.5
Cystine/glutamate antiporter, xCT (requires the 4F2hc protein (TC #8.A.9.2.1)). Functions in the generation of glutathione and plays a role in the oxidative stress response (Wang et al. 2015).