TCDB » SEARCH

« See all members of the family

3.A.1.15.7 Manganese (Mn²⁺) (Km=0.1 μM) and iron (Fe²⁺) (5 μM) porter (inhibited by Cd²⁺ > Co²⁺ > Ni²⁺, Cu²⁺) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).
Accession Number:	Q9XCR9
Protein Name:	SitD aka STM2864
Length:	282
Molecular Weight:	30100.00
Species:	Salmonella typhimurium [90371]
Number of TMSs:	8
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	iron(2+), manganese(2+)

RefSeq:	NP_461785.1
Entrez Gene ID:	1254387
Pfam:	PF00950
BioCyc:	STYP99287:STM2864-MONOMER
KEGG:	stm:STM2864
Gene Ontology GO:0016021 C:integral to membrane GO:0005524 F:ATP binding GO:0042626 F:ATPase activity, coupled to transmembrane m... GO:0006810 P:transport
References (2) [1] “Salmonella typhimurium encodes a putative iron transport system within the centisome 63 pathogenicity island.” Zhou D.et.al. 10085045 [2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.” McClelland M.et.al. 11677609

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MFLTTLLEPF QFDFMVNALM VSVIVAIPCA LLSVFLVLKG WALMGDAMSH AVFPGVVLAY 
61:	IVGIPLAIGA FIAGLFCAIA TGYLDDNSRI KRDTVMGIVF SGMFGAGLVL YVSIQSEVHL 
121:	DHILFGDMLG VSLGDIVQTS VIALGIALII GLKWKDLLLH AFDPHQAKAS GLNTTLLHYG 
181:	LLCMIALTIV ATLKSVGIIL SISLLIAPGA IAILLTRRFA RALGLAVSLS VITAFAGVYL 
241:	SFYLDSAPAP TIVVLFAIVF IAAFIYATWR DRRNEIVPEA QG

3.A.1.15.7
Manganese (Mn²⁺) (Km=0.1 μM) and iron (Fe²⁺) (5 μM) porter (inhibited by Cd²⁺ > Co²⁺ > Ni²⁺, Cu²⁺) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

3.A.1.15.7Manganese (Mn2+) (Km=0.1 μM) and iron (Fe2+) (5 μM) porter (inhibited by Cd2+ > Co2+ > Ni2+, Cu2+) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

3.A.1.15.7
Manganese (Mn²⁺) (Km=0.1 μM) and iron (Fe²⁺) (5 μM) porter (inhibited by Cd²⁺ > Co²⁺ > Ni²⁺, Cu²⁺) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).