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3.A.1.15.7 Manganese (Mn²⁺) (Km=0.1 μM) and iron (Fe²⁺) (5 μM) porter (inhibited by Cd²⁺ > Co²⁺ > Ni²⁺, Cu²⁺) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).
Accession Number:	Q9XCS0
Protein Name:	SitC aka STM2863
Length:	286
Molecular Weight:	30865.00
Species:	Salmonella typhimurium [90371]
Number of TMSs:	9
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate	iron(2+), manganese(2+)

RefSeq:	NP_461784.1
Entrez Gene ID:	1254386
Pfam:	PF00950
BioCyc:	STYP99287:STM2863-MONOMER
KEGG:	stm:STM2863
Gene Ontology GO:0016021 C:integral to membrane GO:0005524 F:ATP binding GO:0042626 F:ATPase activity, coupled to transmembrane m... GO:0006810 P:transport
References (2) [1] “Salmonella typhimurium encodes a putative iron transport system within the centisome 63 pathogenicity island.” Zhou D.et.al. 10085045 [2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.” McClelland M.et.al. 11677609

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FASTA formatted sequence

1:	MNWLVEPFGY QYMLNAMWVS AMVGGLCAFL SCYLMLKGWS LIGDALSHSI VPGVAGAWML 
61:	GLPFSLGAFL SGGLAAGSML FLNQRSRLKE DAIIGLIFSS FFGVGLFMVS LNPMSVNIQT 
121:	IILGNVLAIA PADIAQLAII GAVSLTILLL KWKDLMVVFF DETHARSIGL NPGRLKLLFF 
181:	TLLSVSTVAA LQTVGAFLVI CLVVTPGATA WLLTDRFPRL LMIAVVIGSL TSFLGAWLSY 
241:	WLDGATGGII VVMQTLLFIT AFIFAPKHGL LANRRRARLQ KEPTCS

3.A.1.15.7
Manganese (Mn²⁺) (Km=0.1 μM) and iron (Fe²⁺) (5 μM) porter (inhibited by Cd²⁺ > Co²⁺ > Ni²⁺, Cu²⁺) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).

Cross database links:

Gene Ontology

References (2)

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3.A.1.15.7Manganese (Mn2+) (Km=0.1 μM) and iron (Fe2+) (5 μM) porter (inhibited by Cd2+ > Co2+ > Ni2+, Cu2+) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

3.A.1.15.7
Manganese (Mn²⁺) (Km=0.1 μM) and iron (Fe²⁺) (5 μM) porter (inhibited by Cd²⁺ > Co²⁺ > Ni²⁺, Cu²⁺) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).