TCDB » SEARCH

« See all members of the family

3.A.1.15.7 Manganese (Mn²⁺) (Km=0.1 μM) and iron (Fe²⁺) (5 μM) porter (inhibited by Cd²⁺ > Co²⁺ > Ni²⁺, Cu²⁺) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).
Accession Number:	Q9XCS2
Protein Name:	SitA aka T2763 aka STM2861 aka STY2983
Length:	305
Molecular Weight:	33723.00
Species:	Salmonella typhimurium AND Salmonella typhi [90370]
Number of TMSs:	1
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	iron(2+), manganese(2+)

RefSeq:	NP_457255.1 NP_806464.1
Entrez Gene ID:	1068914 1249290
Pfam:	PF01297
BioCyc:	SENT209261:T2763-MONOMER SENT220341:STY2983-MONOMER
KEGG:	stt:t2763 sty:STY2983
Gene Ontology GO:0046872 F:metal ion binding GO:0007155 P:cell adhesion GO:0030001 P:metal ion transport
References (2) [1] “Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18.” Deng W.et.al. 12644504 [2] “Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18.” Parkhill J.et.al. 11677608

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MTNLHRLKTL LIAGIVAILA LSPAYAKEKF KVITTFTVIA DMAKNVAGDA AEVSSITKPG 
61:	AEIHEYQPTP GDIKRAQGAQ LILANGLNLE RWFARFYQHL SGVPEVVVST GVKPMGITEG 
121:	PYNGKPNPHA WMSAENALIY VDNIRDALVK YDPDNAQIYK QNAERYKAKI RQMADPLRAE 
181:	LEKIPADQRW LVTSEGAFSY LARDNDMKEL YLWPINADQQ GTPKQVRKVI DTIKKHHIPA 
241:	IFSESTVSDK PARQVARESG AHYGGVLYVD SLSAADGPVP TYLDLLRVTT ETIVNGINDG 
301:	LRSQQ

3.A.1.15.7
Manganese (Mn²⁺) (Km=0.1 μM) and iron (Fe²⁺) (5 μM) porter (inhibited by Cd²⁺ > Co²⁺ > Ni²⁺, Cu²⁺) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

3.A.1.15.7Manganese (Mn2+) (Km=0.1 μM) and iron (Fe2+) (5 μM) porter (inhibited by Cd2+ > Co2+ > Ni2+, Cu2+) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

3.A.1.15.7
Manganese (Mn²⁺) (Km=0.1 μM) and iron (Fe²⁺) (5 μM) porter (inhibited by Cd²⁺ > Co²⁺ > Ni²⁺, Cu²⁺) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).