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9.A.17.1.2
The Pex3/Pex16/Pex19 peroxisomal protein importer is for insertion of integral membranes into the peroxisomal and ER membranes. Monotopic hairpin proteins are inserted into ER membranes. These either remain in the ER as resident ER membrane proteins, or are pinched off from the ER as components of new lipid droplets (Zimmermann et al. 2021).

Accession Number:Q9Y5Y5
Protein Name:Peroxisomal membrane protein PEX16
Length:336
Molecular Weight:38643.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Peroxisome membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

RefSeq: NP_004804.1    NP_476515.1   
Entrez Gene ID: 9409   
Pfam: PF08610   
OMIM: 214100  phenotype
601539  phenotype
603360  gene+phenotype
KEGG: hsa:9409   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0005779 C:integral to peroxisomal membrane
GO:0008022 F:protein C-terminus binding
GO:0032581 P:ER-dependent peroxisome organization
GO:0016557 P:peroxisome membrane biogenesis
GO:0016558 P:protein import into peroxisome matrix
GO:0045046 P:protein import into peroxisome membrane

References (9)

[1] “Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D.”  Honsho M.et.al.   9837814
[2] “Peroxisome synthesis in the absence of preexisting peroxisomes.”  South S.T.et.al.   9922452
[3] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.”  Sacksteder K.A.et.al.   10704444
[6] “Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.”  Fransen M.et.al.   11390669
[7] “The membrane biogenesis peroxin Pex16p. Topogenesis and functional roles in peroxisomal membrane assembly.”  Honsho M.et.al.   12223482
[8] “PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins.”  Jones J.M.et.al.   14709540
[9] “The origin and maintenance of mammalian peroxisomes involves a de novo PEX16-dependent pathway from the ER.”  Kim P.K.et.al.   16717127

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MEKLRLLGLR YQEYVTRHPA ATAQLETAVR GFSYLLAGRF ADSHELSELV YSASNLLVLL 
61:	NDGILRKELR KKLPVSLSQQ KLLTWLSVLE CVEVFMEMGA AKVWGEVGRW LVIALIQLAK 
121:	AVLRMLLLLW FKAGLQTSPP IVPLDRETQA QPPDGDHSPG NHEQSYVGKR SNRVVRTLQN 
181:	TPSLHSRHWG APQQREGRQQ QHHEELSATP TPLGLQETIA EFLYIARPLL HLLSLGLWGQ 
241:	RSWKPWLLAG VVDVTSLSLL SDRKGLTRRE RRELRRRTIL LLYYLLRSPF YDRFSEARIL 
301:	FLLQLLADHV PGVGLVTRPL MDYLPTWQKI YFYSWG