2.A.6.2.21
The multidrug (aminoglycosides, β-lactams, fluoroquinolones, macrolides, chloramphenicol, tetracycline, erythromycin, ofloxacin, etc.) efflux pump, MexXY-OprM (Jeannot et al., 2005). The 3-d structurre of OprM (also called OprK) is known (1WP1). RND-type xenobiotic transporters recognize hydrophobic substrates such
as organic solvents by their periplasmic domains and expel them to the
external milieu (Li et al. 2006). The MexXY multidrug exporter is frequently overexpressed in ciprofloxacin resistant cells (Serra et al. 2019). Increased expression or overexpression ofMexXY-OprM efflux pumps is the leading cause of carbapenem (imigenem; meropenem) resistance (Petrova et al. 2019).
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| Accession Number: | Q9ZNG9 |
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| Protein Name: | MexX |
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| Length: | 389 |
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| Molecular Weight: | 41444.00 |
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| Species: | Pseudomonas aeruginosa [287] |
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| Location1 / Topology2 / Orientation3: |
Cell outer membrane1 / Lipid-anchor2 |
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| Substrate |
macrolide, fluoroquinolone antibiotic, ofloxacin, ciprofloxacin, chloramphenicol, beta-lactam, imipenem, tetracycline, amino cyclitol glycoside, erythromycin A, carbapenemcarboxylic acid |
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| Pfam: |
PF00529
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[1] “Expression in Escherichia coli of a new multidrug efflux pump, MexXY, from Pseudomonas aeruginosa.” Mine T. et.al. 9925549
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1: MDRLAARLLA ALVALFLLGC EEAADAGKTA EAPAEVGVIV ARPAPIGITS ELPGRLEAYR
61: QAEVRARVAG IVTRRLYEEG QDVRAGTVLF QIDPAPLKAA LDISRGALPG RGQPRAAADK
121: LKAYADLIKD RAISEREYTE AQTDARQALA QIASAKAELE QARLRLGYAT VTAPIDGRAR
181: RALVTEGALV GEDSPTPLTR VEQIDPIYVN FSQPAAKSRH AAGDPRRPGE GCRRQGHRRA
241: PGPGRRQRVP LAGELLFIDL AVDPGTDTIA MRALFRNPHR ELLPGGYVQV RLQRAVNPQA
301: ITVPDALIRT AQSAVVKVVN PKGLVEDVEV RADTLQGRDW IISRGLKGGE WVIVENAAQH
361: AAGSSVQAVV RQPASADAPS PLAASPAGQ