9.B.325.1.1
The putative two component ABC-4-type transporter (Rafii and Park, 2008). It appears to transport multiple drugs including ethidium and fluoroquinolones. The membrane protein (Q83XH0) is N-terminally truncked and is missing 88 aas. A full length protein is R5TMA6 with 451 aas and 10 TMSs in a 5 + 5 TMS arrangement. This membrane protein has replaced the former one in this TC entry.
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| Accession Number: | R5TMA6 |
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| Protein Name: | Uncharacterized protein |
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| Length: | 451 |
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| Molecular Weight: | 50990.00 |
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| Species: | Clostridium hathewayi CAG:224 [1263067] |
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| Number of TMSs: | 10 |
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| Substrate |
fluoroquinolone antibiotic, ethidium, drug |
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1: MNEAFFQLIS YFFIYSFLGW CMEIAYAALK KKHFYNRGVL NGPLCPVYGI GMILILTFFS
61: SLKESLVFLA IGSAVIATLL EFFTGALMEK LFKKRWWDYS DYKYNLGGYV CIPFSALWGV
121: GAALTLRFIH PLIHMMISRV PALAGQIILI AGLVILAMDF ISVLGVVFQV QKYNTRVEEL
181: AEGMQQISNR LARAIFTRIE KRMAKAHPGA AEEHPEADTG SRVKTRSCEA VPAVFADGCS
241: FHKLVWLFFI GAFLGDITET IFCYATSGIL MSRSSVVYGP FSVVWGLGVV VLTMMLHKYK
301: DRDDRYIFLF GTVVGGAYEY ICSVFTEIAF GTVFWDYSKL PFNLGGRINL LYCFFWGLAA
361: VVWIKLLYPR ISALIERVPV KTGKILSWLM IVFMTVNITI SAMALARYSD RQTGKEAANS
421: IDYFLDDHFP DKRMEWIYPN AIVKDNSAVQ P