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3.D.10.1.8
Quinol:fumarate reductase respiratory complex, FrdABC, where FrdA (627 aas) and FrdB (264 aas) are soluble proteins while FrdC has 218 aas and 5 TMSs.  The crystal structure has been determined at 3.6 Å resolution (Guan et al. 2018).  QFR in anaerobic bacteria catalyzes the reduction of fumarate to succinate by quinol in the anaerobic respiratory chain. The electron/proton-transfer pathway in the anaerobic sulphate-reducing bacterium Desulfovibrio gigas involves a homo-dimer, each protomer comprising two hydrophilic subunits, A and B, and one transmembrane subunit C, together with six redox cofactors including two b-hemes. One menaquinone molecule is bound near heme bL in the hydrophobic subunit C. This location of the menaquinone-binding site differs from the menaquinol-binding cavity proposed previously for QFR from Wolinella succinogenes (TC#3.D.10.1.3). The bound menaquinone may serve as an additional redox cofactor to mediate the proton-coupled electron transport across the membrane. Guan et al. 2018 proposed electron/proton-transfer pathways during the quinol-dependent reduction of fumarate to succinate in the D. gigas QFR.

Accession Number:T2GB49
Protein Name:Putative fumarate reductase flavoprotein subunit
Length:627
Molecular Weight:68793.00
Species:Desulfovibrio gigas (strain ATCC 19364 / DSM 1382 / NCIMB 9332 / VKM B-1759) [1121448]
Substrate hydron, fumarate(2-), electron

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Structure:
5XMJ     

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FASTA formatted sequence
1:	MQIYHTDVLC IGAGLAGERV AVEASMAGLK TIMLSLVPPR RSHSSAAQGG MQAALGNAIM 
61:	GDGDSPDVHF ADTVKGSDWG CDQEVARIFA DTAPIVMREV AHWGVPWNRV VPGKHTYYKG 
121:	GKPFEAEEKA EKAGLIHARA FGGTAKWRTC YTADGTGRSV LNTLDTKCLQ YGVTVHDRMQ 
181:	AEALIHDGEN CLGCIARCLR TGELVAYLAT STLIATGGYG RIYKATTNAV ICDGGGQIIA 
241:	LDTGLVPMGN MEAVQFHPTG TVPTDILVTE GCRGDGGTLL DVNQYRFMPD YEPDKAELAS 
301:	RDVVSRRMTE HMRKGLGVKS PYGDHLWLDI RHLGEKHITT KLREVYDICT NFLGVNPIHQ 
361:	LIPVRPTHHY SMGGVRTNRD GAAYGLKGLF SAGESACWDM HGFNRLGGNS LAETVVAGRY 
421:	IGKRMVEFTK GATPSFGMQY VEDAHKKVQE RITDIVTGRK GKENTFKIRD EMHDIMMEGV 
481:	GIFRNGTDLQ KAVNKLEELY DRSQKISLSS ACKGMNPELS TALRIRGMVK LAQCTAYGAL 
541:	MRTESRGAHT REDFPERNDK EWLNRTLSYW KEGASMPTLE YEEASPYYEM PPGDRGYGGG 
601:	VTIANELPPE KFVIPEAAKE NLKKAKL