2.A.6.2.49
Multidrug resistance exporter, AcrABZ. Exports tigecycline and many other drugs (Nielsen et al. 2014; Li et al. 2016; Yuhan et al. 2016; He et al. 2015; Bialek-Davenet et al. 2015). AcrA-AcrB-AcrZ-TolC is a drug efflux
protein complex with a broad substrate specificity. AcrZ (YbhT) binds
to AcrB and is required for efflux of some but not all substrates,
suggesting it may influence the specificity of drug export (Hobbs et al. 2012; Du et al. 2015). K. pneumoniae TolC plays a role in resistance towards most antibiotics, suggesting that it interacts
with the AcrAB efflux pump (Iyer et al. 2019). Expression as well as missense mutations in the crrB gene promotes resistance to odilorhabdin class compounds including NOSO-502 (Pantel et al. 2021).
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| Accession Number: | W9BHF5 |
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| Protein Name: | Multidrug efflux pump subunit AcrB |
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| Length: | 1038 |
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| Molecular Weight: | 111986.00 |
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| Species: | Klebsiella pneumoniae [573] |
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| Number of TMSs: | 12 |
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| Substrate |
tigecycline, tigecycline, drug |
|---|
1: MPHFFIERPI FAWVIALFIV LTGLLSIPRL PVAQYPEVAP PGIIISVSYP GASPEVMNTS
61: VVSLIEREIS SVDNLLYFES SSDTTGMASI TVTFKPGTDI KLAQMDLQNQ IKIVESRLPQ
121: SVRQNGINVE AANSGFLMMV GLKSPSGAYQ EADLSDYFAR NVTDELRRVP GVGKVQLFGG
181: EKALRIWLDP MKLHSYGLSV TDVLSAISQQ NVIVSPGRTG DEPATSSQEV TYPITVKGQL
241: SSVEEFRNIT IKSQVSAARV TLADVARVES GLQSYAFGIR ENGVPATAAA IQLSPGANAI
301: STASGIRARL TELSGVLPEG MTFTVPFDTA PFVKLSILKV VETFVEAMVL VFFVMLLFLH
361: KIRCTLIPAI VAPVALLGTF TVMLLSGYSI NILTMFGMIL AIGIIVDDAI VVVENVERLM
421: EDKKMSPQDA TREAMREITP AIIGITLVLT AVFIPMAFAS GSVGIIYRQF SISMAISILL
481: SAFLALTLTP ALCATLLKPH GIHQGKSSVF SAWFNAHFHR LTSFYATGLG FVLKRTGRMM
541: MIYAALCLAL FAGLSTLPSS FLPDEDQGYF MSSIQLPSDA TMQRTLKVVD TFEEEIAHRQ
601: AVESNIMILG FGFSGSGQNS AMAFTTLKDW RQRKGTTAQE EADHIRSQMA NVPDAVTMSL
661: LPPAISDMGT SSGFTYYLQD RGGKGYQALK KAADELIVQA NHNPHLADVY IDGLGEGTSL
721: SLHVDREKAE AMGVSFDEIN QTISVAAGSN YVNDYTNNGR VQQVIVQADA PYRMQPEQLL
781: ALSVKNRLGQ MLPLSTFVTL SWNVAPQQLI RYQGYPAIRI TGSSAQGKSS GTAMAAMDNL
841: AKHLPPGFAG EWAGSSLQEK ESASQLPGLI VLSVLVVFMV LAALYESWSI PFAVMLVVPL
901: GLLGAVLAVS VTNMTNDVFF KVGLITLIGL SAKNAILIIE FARQLMKEGK SLIDATLTAA
961: KLRLRPILMT SLAFTLGVVP LMLASGASDS TQHAIGTGVF GGMISGTLLA IFFVPVFFVT
1021: ITRFTGMRKY RLGNSRNG