1.A.1.10.10
The insect (cockroach) Na+ channel. Batrachotoxin, pyrethroids, and BTG 502 share overlapping binding sites (Du et al., 2011). Insecticides tagetting Na+ channels include indoxacarb and metaflumizone (Casida and Durkin 2013). They preferably
bind to and trap sodium channels in the slow-inactivated non-conducting state, a mode of action
similar to that of local anesthetics (Jiang et al. 2015). Asp802 is involved in gating and action, but not binding, of pyrethroid insecticides (Du et al. 2010).
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| Accession Number: | O01307 |
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| Protein Name: | Para sodium channel |
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| Length: | 2031 |
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| Molecular Weight: | 229998.00 |
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| Species: | Blattella germanica (German cockroach) [6973] |
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| Number of TMSs: | 22 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
Na+ |
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| Pfam: |
PF11933
PF00520
PF06512
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GO:0001518
C:voltage-gated sodium channel complex
GO:0005248
F:voltage-gated sodium channel activity
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[1] “A single amino acid change in the para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach.” Dong K. et.al. 9066120
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1: MSDDSSSISE EERSLFRPFT RESLAAIEAR IAEEYAKQKE LEKKRAEGEV RYDDEDEDEG
61: PQPDATLEQG APIPVRMQGL FPPELASTPL EDIDPFYHNQ RTFVVVSKGK DIFRFSATDA
121: MWILDPFNPI RRVAIYILVH PLFSLFIITT ILTNCIFMIM PTTPTIESTE VIFTGIYTFE
181: SAVKVMARGF ILQPFTYLRD AWNWLDFVVI ALAYVTMGID LGNLAALRTF RVLRALKTVA
241: IVPGLKTIVG AVIESVKNLR DVIILTMFSL SVFALMGLQI YMGVLTQKCI KNFPINGSWG
301: ELNDENWHAF CSNNTNWYFP EGAPEVPLCG NSSGAGTCPP DYTCLQGFGE NPNYGYTSFD
361: TFGWAFLSAF RLMTQDYWEN LYQLVLRSAG PWHMLFFIVI IFLGSFYLVN LILAIVAMSY
421: DELQKKAEEE EAAEEEALRE AEEAALAKEA KKLRQADKLA AQELAAAQEL AGANLAKSPS
481: GSSSRSYELF INQKDGNNDN KRENMSIRSE GGDSISEHKG RVGANGTAIR KVSAASLSLP
541: GSPFNHRRGS QGSHHFTIRN GRGRFVGPPG GDRKPLVLST YLDAQEHLPY ADDSNAVTPM
601: SEENGAIVVP VYYASLGSRH SSYTSHASRI SYTSHGDLLG AGNKSQTKIN QLRARSVRNN
661: PSQVPNSTPY MNASADSDDG AVKAKHTDNP FIEQMQQTTI VDMNDVMVLN DIIEQAAGQQ
721: SRASEHGVSI YYFPTDEDDE GPTVKEKVLA ICMRGIDIFC VWDCCWLWLK FQEYVALLVF
781: DPFVELFITL CIVVNTLFMA LDHHDMNKDM DKALKSGNYF FTATFAIEAT LKLIAMSPKY
841: YFQEGWNIFD FIIVALSLLE LGLEGVQGLS VLRSFRLLRV FKLAKSWPTL NLLISIMGRT
901: VGALGNLTFV LCIIIFIFAV MGMQLFGKNY YDNVERFPDG DMPRWNFTDF MHSFMIVFRV
961: LCGEWIESMW DCMLVGDWSC IPFFLATVVI GNFVVLNLFL ALLLSNFGSS NLSAPTADNE
1021: TNKIAEAFER FSRFFNWIKR SALNVAKMLR AKLTNQISDQ TPDAHERDTD LDLTADEILA
1081: DGIVYRDKKS PKEQTQLEVA IGDGMEFTIH GDLKNKLKKD KLMMNSTKVI GNSLNHKDNR
1141: IESGDYLHNR QDEDTLSTGS YGSHKNRPYK DDSHKGSAET MDGEEKKDAS KEDLDQEGEG
1201: EEDGEGEGPL EEDMVLDAGT EDVMMSEYPA DCCPDHCYKR FPFLAGDEDS PFWQGWGNLR
1261: LKTFQLIENK YFETAVITMI LLSSLALALE DVHLPHRPIL QDILYYMDRI FTVIFFIEML
1321: IKWLALGFKK YFTNAWCWLD FIIVMVSLIN FVASLVGAGG IQAFKTMRTL RALRPLRAMS
1381: RMQGMRVVVN ALVQAIPSIF NVLLVCLIFW LIFAIMGVQL FAGKYHKCVD SNSTTLSHEI
1441: IPDRNACIAE NYTWENSPMN FDHVGKAYLC LFQVATFKGW IQIMNDAIDS RELHKQPIRE
1501: TNIYMYLYFV FFIIFGSFFT LNLFIGVIID NFNEQKKKAG GSLEMFMTED QKKYYNAMKK
1561: MGSKKPLKAI PRPKWRPQAI VFEICTDKKF DMIIMLFIGF NMLTMTLDHY QQSKQFSDVL
1621: DYLNMIFIVI FSSECLMKIF ALRYHYFKEP WNLFDFVVVI LSILGLVLSD IIEKYFVSPT
1681: LLRVVRVAKV GRVLRLVKGA KGIRTLLFAL AMSLPALFNI CLLLFLVMFI FAIFGMSFFM
1741: HVRDKGGLDD VYNFKTFGQS MILLFQMSTS AGWDGVLDGI MNEEDCNKPN SEIGYPGDCG
1801: SATVGIAFLL SYLVISFLIV INMYIAVILE NYSQATEDVQ EGLTDDDYDM YYEIWQQFDP
1861: DGTQYIRYDQ LSDFLDVLEP PLQIHKPNKY KIVSMDIPIC KGDLMFCVDI LDALTKDFFA
1921: RKGNPIEESA ELGEVQPGRP DEVGYEPVSS TLWRQREEYC ARLIQNAWRK HKQQRQGAPG
1981: EDSDEAGDDP ELQDRHQTAV LVESDGFVTK NGHRVVIHSR SPSVTSRSTD V