1.A.1.10.11
Sodium channel of 2215 aas, VmNa. An L925V mutation in the channel domain renders the honey bee mites resistant to pyrethroids such as tau-
fluvalinate and flumethrin (González-Cabrera et al. 2013).
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| Accession Number: | Q86D77 |
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| Protein Name: | Sodium channel protein |
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| Length: | 2215 |
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| Molecular Weight: | 248497.00 |
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| Species: | Varroa destructor (honeybee mite) [109461] |
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| Number of TMSs: | 17 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
sodium(1+) |
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1: MPPAPAETAL SANTEQPAFS TSSATPHALA LPIAEDGVHA DHDDDDFHDH DIEHMLGDEP
61: QSIFRPFTRE SLATQLARLA EEAAKKAQLE KMREEGIEPE PQFYHHKEAP DPDPGLEAGG
121: PLPKRIVNDF PPELIATPVE EIDKYYENKR TFMVISKGKD IFRFSSTNAL WILSPFNPIR
181: RLAICILVHP LFSFFIIVAI LVNCVLMTMP ANGKIEQTET IFTTIYTFES FIKILARGFI
241: LERFTYLGDP WNWLDFIVIT LAYVTMFVNL GNLSALRTFR VLRALKTVAI VPGLKTIVGA
301: VIESVKNLRD VIILTMFSLS VFALMGLQIY MGVLTQKCVQ QPPAGLSPPE WYDFVHNETH
361: WFKDSNGDFP LCGNGTGAKQ CSADYICMQG IGENPNYGFT NFDTFGWAFL SAFRLMTQDY
421: WESLYQMILR SAGPWHMCFF VVIIFLGSFY LVNLILAIVA MSYDDLQKRA EEEAEEDRLL
481: EEAMRLEEEA REEARAEAAN RVAEAKREAR EVRKDERDAA LAREMQAATA AAGGGAGKKG
541: VNQVPNQANH GGQLAKSPSE YSMRSLDAGT GHPSVPPDER ASLRSIDGAD LLQHTGHGGP
601: HSQQQQQLYS QSRHNNGKVR KASLSLPGSP FNIRRGSRSS GQWRPSGHPA NGGGGAAGRR
661: PGGGGGQPCY GGAKPLLRQT YVDAQEHLPF ADDSAAVTPM SEDNGAIIIP LYSNLQHSRR
721: SSYTSHSSRL SYTSHGEVYC LTKESQLRSR SRNLQNYFYD QETRLDSEDY ILSKIKQVNK
781: PYMEPSTRHP MVDMRDVMVL NDIIEQAAGR QSKASERVSI YYFSTDDEDE GSLEEEDVEA
841: KWKEKCLAGC LKCIDIFCVW DCCWCWIRAQ EIIGLIVFDP FMELFITLCI VVNTLFMAMD
901: HHDMDRDFEN VLRSGNYFFT ATFAIEATMK LMAKSPKNYF KEGWNIFDFI IVALSLLELG
961: LEGVQGLSVL RSFRLLRVFK LAKSWPTLNL LISIMGKTIG ALGNLTFVLG IIIFIFAVMG
1021: MQLFGKNYLD NKCLFPEQQV PRWNFLDFMH SLMIVFRVLC GEWIESMWDC MWVSGWPCIP
1081: FFLATVVIGN LVVLNLFLAL LLSSFGASNL SQANPDSGDT KKLQEAIDRF HRAGRWIKKK
1141: FRDLFMLCSG KQRNQISDQT YAEDLDLDTG VIIMDGQVIK KDSPTPELID GLDVGFQADK
1201: QQAQVIVMQK LKNNSRPIIG DSKEFSNKVH PGPDFCLVKP NDNGEGLVQD TELGASTPLS
1261: SPSCIVEQPL SHDSVGLPPG GQQRTTTTTA AVGGGATPAM ENNLTTPLTA GTGLTSVRFS
1321: GEPPNLDQHE NNPQFADATP VSLAASKDKS SGDDGDEVDG KLEGLADDVG DGGDATVSLP
1381: ANAEGKENAG GSDVGAEEDK EQLEGGALET AASDLIIPEL PADCCPECCY VKFACCCIFD
1441: DSQPLFAKYK LYRSQAFALV ENEYFETIVV VLILTSSLAL ALEDVNLKQR QWLINILNVM
1501: DKTFTVIFFS EMLLKWLAFG FQKYFTNAWC WLDFVIVLVS VINLVATWLG AGKIQAFKTM
1561: RTLRALRPLR ALSRFQGMRV VVNALVQAIP AIFNVLLVCL VFWLIFSIMG VQMFAGRFYH
1621: CVDANNSQLN STFIPNKEAC INNNFTWKNP MINFDNVLNA YLALFQVATF KGWTEIMAHA
1681: TDSRGKDDQP DYEVNIYMYL YFVFFIIFGA FFTLNLFIGV IIDNFNEQKK KAGGSLEMFM
1741: TEDQKKYYSA MKKMGSKKPA KAIPRPRFKL QAMIFDLTTN RMFDMAIMIF IVLNMTVMAM
1801: EHYQQSDFFE SILERLNIFF IAVFTAECVL KIFALRWHYF KEPWNMFDFV VVILSILGTV
1861: LKDLIAAYFV SPTLLRVVRV VKVGRVLRLV KGARGIRTLL FALAMSLPAL FNICLLLFLV
1921: MFIYAIFGMS FFMNVKHRYG VDENFNFETF GQSMILLFQM CTSAGWSDVL AAIMDETDCE
1981: EPTIDEDGET EGNCDKKGIA VAYLVSYLII SFLVIINMYI AVILENYSQA TEDVQEGLTD
2041: DDYDMYYEIW QQFDPKGTQY LPYSHLSNFV NALEEPLQIP KPNKYKLIAL DIPICKGDMV
2101: YCVDILDALT RDFFARKGHQ IEEPPELTEQ VIHIDRPGYE PISSTLLRQR QEYCARVIQH
2161: AWRRSKGEYD DSDEETGGAQ DTAIVVVDGD DTKTKVVIRP SPAPLADASR SDAQV