1.A.1.10.13
Voltage-sensitive Na+ channel of 2821 aas and 24 TMSs (Cohen et al. 2009). Pyrethroid, an insecticide,
binds to insect Na+ channels at two sites called pyrethroid,receptors, PyR1 (initial) and PyR2, located in the domain interfaces II/III and I/II, respectively, and binding residues have been identified (Du et al. 2015).
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| Accession Number: | Q9W0Y8 |
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| Protein Name: | Sodium channel protein 60E |
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| Length: | 2821 |
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| Molecular Weight: | 318625.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 21 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
sodium(1+) |
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1: MSDDQATFND EKAVAKHQVV AYTQRSQVKH ENRHIQLVRE YGFHPRTKAS VEDGDVLPRK
61: FEPFPEHMYG KPLEEIDTFI YEETFCVVSK RFRKNYIHRF TGTKSLFLFY PWSPARRVCV
121: YIATNQFFDY CVMATILFNC IFLAMTETVE EAEYIFLAIY SIEMVIKIIA KGFLLNKYTY
181: LRNPWNWLDF VVITSGYATI GMEVGNLAGL RTFRVLRALK TVSIMPGLKT IINALLHSFR
241: QLAEVMTLTI FCLMVFALFA LQVYMGELRN KCVRQVPTDW TNVSHTDWQI WVNDTDNWLY
301: DEDELPVLCG NLTGARHCPF EYVCLCVGEN PNHGYTNFDN FMWSMLTTFQ LITLDYWENV
361: YNMVLATCGP MSVSFFTVVV FFGSFYLINL MLAVVALSYE EEAEITNEER KKDLLDHRDD
421: STFSFDPSVL NVKKLNKNNK KKIDSRKGVL LASYSKKKTR RKKTKGGKEG GTNGNGNGSN
481: GDDNKSHSAT PSPGPSPRHS ATERPSALTM QAQKQYQQME QQHKLAKSGS GGSNNPMAPT
541: PKGRISFQDS GMGVKNPNML YPSDYKGQLI ANSGQPSSNS SGVNRESSQD DSGVVDDHEE
601: QDTTNDMGHV STVELALSPR EVRLIKCNGN IARIKNHNVY ALHQEFSSEV VVIDDLPDRN
661: CDRCVHWCTD YESWLQFQNC LYKVVRDPLF ELAITLCIVL NTAFLAMEHH GMSESFRNAL
721: DVGNKVFTSI FTFECIVKLM ALSKDFFLCG WNIFDLLIVT ASLLDIIFEL VDGLSVLRGL
781: RLLRVLKLAQ SWTTMKVLLS IIISTIGALG NLTLILVIVI YIFAVIGMQL FSKDYTPEKF
841: DPDPVPRWNF NDFFHSFMMI FRILCGEWIE PLWDCMRAEE EQGASTCFAI FLPTLVMGNF
901: MEVGEESKLA RSIERVRDLI RKKRQERKDR KERKFAEKFQ QIVLDAQQAH AQTLSHQAAV
961: GLERGDKPGV LAETKFHRLS YQESMNRPVS GSDFGFQIPL HDGLHTIVDG LEYDDTGDLP
1021: EQIQLQAHPL PPTSDSMPPT YESAMMATTG GSFSSVNGNG TCQNLTPFVQ AERRLQHQIS
1081: SGVSTQQYDS REEATYTESI ELLGQYNSTD TDPYANDQRS GCGSFNRGDS LQDNSSRRYG
1141: SEEHDEAFLK YQKSLLTRSP SYRKSLDRLS QSSGQSQRSL LKSEEAEMRR HSSGQSLNSM
1201: SIEQDELLSQ QGNLREELLN CDQKELFQFL QEEEELQKGT KLRRISNVMR SRRPSSQMGQ
1261: PENETMVEHS EFDNIIQSFE KELEEIKRST TSLERKLSNL SEPSPAADEA TKAIMEHIAI
1321: ITGASERSAA DEVVLPLNPY DSYDLSSVPR RSQSVSAAAQ RQSVKLKRRS LEKQRKIDED
1381: FSISNEIRKI CDQIHAPFVA MEAMAVAATS ASQAQPNQSP FLRRKVDPFT VQFDRFKRLS
1441: LIERVEEVPE EEKPISTLRI ESEKMPRKFL HGPDQLRLDS LSLKSTNSYE NLLIQKQKLG
1501: MATPPAVPAT PPTSLKSSIE PPTLAQISSL KTTPPLAALT EHQQHFHATS IQAAPTPAHT
1561: HAHSQAHAHS MAGQRRRMEH PQSTLDKAAS FQSARTESHS SGAADASSAL ALAMAQKTEQ
1621: SQSTAPDATQ KPSAFTRLTE KPWHCLVSYV DDLTVGGRRN SQGAYNDPMT FPSYGATKAA
1681: KVPDDCFPQK CYDHFYFRCP WFMSCMDTQS AKHWTRVRTA VLTVVDTPAF EWFVLVLIFA
1741: SSITLCFEDI NLDKNKTLKR VLYWINFSFC LIFVVEMILK WLALGFSKYF TSFWTILDFI
1801: IVFVSVFSLL IEENENLKVL RSLRTLRALR PLRAISRWQG MRIVVNALMY AIPSIFNVLL
1861: VCLVFWLIFS IMGVQFFGGK FFKCVNEMGE LLPITEVNDK WDCIEQNYTW INSKITFDHV
1921: GMGYLALLQV ATFEGWMEVM ADAVDARGVD LQPQREANLY AYIYFVIFIV CGSFFTLNLF
1981: IGVIIDNFNM LKKKYEGGVL EMFLTESQKH YYTAMKKLGR KKPQKVIKRP INHFLAMFYD
2041: LSNSRRFEIA IFVLIFLNML TMGIEHYDQP HAVFFILEVS NAFFTTVFGL EAIVKIVGLR
2101: YHYFTVPWNV FDFLLVLASI FGILMEDIMI DLPISPTLLR VVRVFRIGRI LRLIKAAKGI
2161: RKLLFALVVS LPALFNIGAL LGLITFIYAI LGMSLFGNVK LQGALDDMVN FQTFGRSMQL
2221: LFRLMTSAGW NDVLESLMIQ PPDCDPFIHG HTNGNCGHPL LAITYFTSFI IISYMIVINM
2281: YIAIILENFN QAHQEEEIGI VEDDLEMFYI RWSKYDPHAT QFIHFSQLSD FIASLDPPLG
2341: ISKPNNVALV SFNLPISKGN KIHCLDILHA LVKHVLGHVE ETDNFKQLQE QMDVKFKKQF
2401: PTRKELEIVS STRIWKRQEK AAKTIQTGWK EYLRRKREKE RSNSGDSATQ TSSPGGWQSK
2461: LSALNFFHLQ VSRRGTACSS RASSRKSSRA SDASDLSELA GPWLNLPLML VSGADEVVKD
2521: IKQQNDELGK RGSIFVEAPR ASRRRSFYNF FLRHQDAVDD SLTSPSVHRK TAMNNTTNTT
2581: SNSASTSGTA SSTATAPATG CGPAATSASD SDRHQAVGGG SAPSRKRASS FIRKKPPLER
2641: GLSAQSALRV NKNAFVSEAS APEVIVTRPS PEQQTHPHSL SLRPDNATLV HVLVHRESEE
2701: YKEEDESSPS VSGNGNGFGV GLDMLSKQPP PQIRITTGSV ESSMDTCAMP TVQIMVDSPK
2761: DPPRGDFSSA PIDDVGAPID VNVQGDTSQV FYDYNPEKAT DDQGNGQDET AQFESLPDRQ
2821: R