1.A.1.10.14
The voltage-gated Ca2+ channel (VDCC; CAV2), α-subunit of 2027 aas and 24 TMSs in four domains, each
with six transmembrane segments and EEEE loci in the ion-selective filter, typical of
VDCCs in vertebrates. CAV2 primarily localizes in the distal part
of flagella and is transported toward the flagellar tip via
intraflagellar transport (IFT) although CAV2 accumulates near the flagellar base when IFT is
blocked. Thus, Ca2+ influx into Chlamydomonas flagella is
mediated by the VDCC, CAV2, whose distribution is biased to the distal region of the flagellum, and this is required for flagellar waveform conversion (Fujiu et al. 2009).
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| Accession Number: | A8JF90 |
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| Protein Name: | Voltage-gated Ca2+ channel, alpha subunit |
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| Length: | 2027 |
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| Molecular Weight: | 219710.00 |
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| Species: | Chlamydomonas reinhardtii [3055] |
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| Number of TMSs: | 19 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
Ca2+ |
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1: MTYPEYSLLF LRKSNFVRKW CVYTTHTRVF EWTILAAIIA NCVTLAVSSN RQDFDETPLG
61: RTLVNLEYLW VAIFTTEALL KIVAMGFVLA PGTYLRDGWN IVDFTVVALG FVDIFSSGNL
121: TALRTVRVLR PLRAITRIRG MRILVTTMIA ALPMLIDVFA LCAFTFFIFG LVAVQLFSGR
181: MTHRCAVPVF DGSYTEVVGG STFYRNVTYV VQDEESGDGC SGPMSEGLEW VDVNGTAVAL
241: AGGDGLGRAC PDGLYCTNYG NPNYGITSFD HILWAWLTIF QMITQEGWTD IMYFTSDTIT
301: WWVWPFFVAL VAFGSFYIIN LALAVLFMQF SNDNHADDPS KKKSGRQGSG DGQRQGDKAG
361: AGGGGAANSG GEHKDSDSES SMSDVGSEED ERLRPTMAEV TGLRTVGQHS TKLKSATSSP
421: LTMDEVERLS PFRRRLYRVA ASRWLELFTM SLIILNTVLM CINWFEMPES VERATNYINY
481: VFTVYFLVEM ILKMTAFGLV RYFRDGMNIF DCLVVVISVT EMVLDIIPSV SGLGPLSVLR
541: AFRLLRIFRL ARSWKELNLI IRAIFKSITS TTYLLLLMLL FMFIASLMGM QLFGYKFMFC
601: DYVEGAAPTC PLGWNVWGQC PDHFHCYLPC MSADYGSWVN ATGSFYNDLA YCERFCANDQ
661: AAAAADANAT SPDVAAAGGC EYLAMVGKSE VPRANFDNIF WSMYTVFQIL TMENWNNIMY
721: DGMRSTTPWC AAYFVAVVLI GTYLVFNLFV AILLDNFSSV FGESDDSDGS GSGSLKADGQ
781: AAGSGKHKSR RSSSSSSDTD SLHDSDLDAG EAGDAFGSMR SHCEYAGNEF ADSPHADDAS
841: RPSSPGGTYY STEGYHTRFS REYERAHGAG TGRGSGEGGG AGYTTHEAHA QRATGGPGGG
901: HAPTGASPAP QQGEGEDVAA AGGADGPGAG AGPGIGIGIG GSRRAPPTLH LPDSPSAVGA
961: LPPIGPAHQP VPSPKTPFSA GIGYAHPSPG AKGGHPVTQS PSDLSRGLRG VLRKVVPVDD
1021: EGRPGSSHSG SQPPRPSLRP VSAAPRPLSS VRGGGGNRVR PVSGRPPVKF DGVDSGREGG
1081: GGGGVTFAND AVSRRASFIA AHQTAAAGSQ GAGEANGGST SQGGLAASIS RSIGRSIGRS
1141: VSRTLQRAMS SIRSIREVRH NEHLAKQIKG RSLLLLDPEH WVRWRAARMV HHTHFETVIL
1201: GLIVLSSITL ALDSPGLDPD SQLAQALRYL DYIFLGAFTL EAALKIITFG FAFTGKHAYI
1261: RNGWNVLDFI IVLAGYALLA VELSGANGED LKMLRILRTL RALRPLRAAS RYEGLKLVVN
1321: TLFAVLPAMA DVALVCALFY IIFSILAVNL FKGQLYNCID ADSGERLDPY YLLPPGQTLE
1381: RGMCEAGSIT VNSSVYTAAR NISLMPYNIT TSWVNPVANF DNVAISMLTL FQIATLELWV
1441: DIMFTAVDVA GVGKQPLWNN HPVVILFFIL VVIVCCFFVL NLFIGVTLDK FTELQQAQTA
1501: SSVFVTPQQQ NWVDVQKLLL RTGMTSRPAR FEEPAWRAGL YDFVMGSVFE EFILITIVVN
1561: VLFMAMVHAD MSPQWQACMT YTNLIFTCVF VIEAALKIMA FGAFAYFRDR WNAFDFFVVV
1621: ISVASVVLDF SGTQNLSFMP VLRVLRVVRV VRLIRRAVGM RRLLLTLVQS LPALGNVGGV
1681: MVLFFFVYAV IGMNLFGGIK FGDYISRHAN FNNFGKAMLL LFRQASMARY YEARFLAVSP
1741: GRMITGESWS GVMQDCMITH NCVLITANVT APATNATLVE GTYLSPNDPS MSGLPPDVHQ
1801: NQCSLSPWAA VVYFPTFIVL CGFILLNLVI AIILENMITS ENDEGLTVSK SLVGQFVDAW
1861: SQVDNCATGY VHASKLPLII SHIEPPLGTR GQGNARAVTQ AVIMSVDVPI HENNTVTFVE
1921: TLHALAGRVA GTELPEIEEE WLVEKYSKRL PDGGAAFPKL TAAHFHAALY VQAAIRGFMA
1981: RHKMRGMMQT LAGGPGGAGG GTGSGSGADA DGLHNGGKAF EKGGKVA