1.A.1.10.17
Voltage-gated Na+ Channel protein of 2,139 aas and 24 TMSs. Mediates voltage-dependent sodium ion permeability of excitable membranes. 3-d modeling revealed spacial clustering of evolutionarily conserved acidic residues at extracellular sites (Vinekar and Sowdhamini 2016).
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| Accession Number: | A5I843 |
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| Protein Name: | Sodium channel protein |
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| Length: | 2139 |
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| Molecular Weight: | 240085.00 |
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| Species: | Anopheles gambiae (African malaria mosquito) [7165] |
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| Number of TMSs: | 21 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
Na+ |
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1: MTEDSDSISE EERSLFRPFT RESLQAIEAR IADEEAKQRE LERKRAEGES DFGRKKKKKE
61: IRYDDEDEDE GPQPDPTLEQ GVPVPVRMQG SFPPELASTP LEDIDSFYSN QRTFVVISKG
121: KDIFRFSATN ALYVLDPFNP IRRVAIYILV HPLFSLFIIT TILVNCILMI MPTTPTVEST
181: EVIFTGIYTF ESAVKVMARG FILQPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT
241: FRVLRALKTV AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC
301: IKEFPLDGSW GNLTDESWEL FNSNDTNWFY SESGDIPLCG NSSGAGQCDE GYICLQGYGK
361: NPNYGYTSFD TFGWAFLSAF RLMTQDYWEN LYQLVLRSAG PWHMLFFIVI IFLGSFYLVN
421: LILAIVAMSY DELQKKAEEE EAAEEEALRE AEEAAAAKAA KLEAQQAAAA AAANPEIAKS
481: PSDFSCHSYE LFVGQEKGND DNNKEKMSIR SEGLESVSEI TRTTAPTATA AGTAKARKVS
541: AGVATIQKAS LSLPGSPFNL RRGSRGSHQF TIRNGRGRFV GVPGSDRKPL VLSTYLDAQE
601: HLPYADDSNA VTPMSEENGA IIVPVYYANL GSRHSSYTSH QSRISYTSHG DLLGGMTKES
661: RLRNRSARNT NHSIVPPPNA NNLSYAETNH KGQRDFDLTQ DCTDDAGKIK HNDNPFIEPA
721: QTQTVVDMKD VMVLNDIIEQ AAGRHSRASD HGVSVYYFPT EDDDEDGPTF KDKALEFLMK
781: MIDIFCVWDC CWVWLKFQEW VAFIVFDPFV ELFITLCIVV NTLFMALDHH DMDPDMEKAL
841: KSGNYFFTAT FAIEATMKLI AMSPKYYFQE GWNIFDFIIV ALSLLELGLE GVQGLSVLRS
901: FRLLRVFKLA KSWPTLNLLI SIMGRTMGAL GNLTFVLCII IFIFAVMGMQ LFGKNYVDNV
961: DRFPDHDLPR WNFTDFMHSF MIVFRVLCGE WIESMWDCML VGDVSCIPFF LATVVIGNLV
1021: VLNLFLALLL SNFGSSSLSA PTADNETNKI AEAFNRISRF SNWIKMNLAN ALKFVKNKLT
1081: SQIASVQPTG KGVCPCISSE HGENELELTP DDILADGLLK KGIKEHNQLE VAIGDGMEFT
1141: IHGDLKNKAK KNKQIMNNSK VIGNSISNHQ DNKLDHELNH RGVSLQDDDT ASIKSYGSHK
1201: NRPFKDESHK GSAETMEGEE KRDASKEDLG IDEELDDEGE GDEGPLDGEL IIHAEEDEVI
1261: EDSPADCCPD NCYKKFPVLA GDDDAPFWQG WGNLRLKTFQ LIENKYFETA VITMILLSSL
1321: ALALEDVHLP QRPILQDILY YMDRIFTVIF FLEMLIKWLA LGFKVYFTNA WCWLDFIIVM
1381: VSLINFVASL CGAGGIQAFK TMRTLRALRP LRAMSRMQGM RVVVNALVQA IPSIFNVLLV
1441: CLIFWLIFAI MGVQLFAGKY FKCVDKNKTT LPHEIIPDVN ACKAENYSWE NSPMNFDHVG
1501: KAYLCLFQVA TFKGWIQIMN DAIDSRDVGK QPIRETNIYM YLYFVFFIIF GSFFTLNLFI
1561: GVIIDNFNEQ KKKAGGSLEM FMTEDQKKYY NAMKKMGSKK PLKAIPRPRW RPQAIVFEIV
1621: TNKKFDMIIM LFIGFNMLTM TLDHYKQSET FSAVLDYLNM IFICIFSSEC LMKIFALRYH
1681: YFIEPWNLFD FVVVILSILG LVLSDIIEKY FVSPTLLRVV RVAKVGRVLR LVKGAKGIRT
1741: LLFALAMSLP ALFNICLLLF LVMFIFAIFG MSFFMHVKDK SGLDDVYNFK TFGQSMILLF
1801: QMSTSAGWDG VLDGIINEED CLPPDNDKGY PGNCGSSTIG ITYLLAYLVI SFLIVINMYI
1861: AVILENYSQA TEDVQEGLTD DDYDMYYEIW QQFDPDGTQY VRYDQLSDFL DVLEPPLQIH
1921: KPNRYKIISM DIPICRGDMM FCVDILDALT KDFFARKGNP IEETAELGEV QQRPDEVGYE
1981: PVSSTLWRQR EEYCARLIQH AWKRYKQRHG GGTDASGDDL EIDACDNGCG GGNGNENDDS
2041: GDGATGSGDN GSQHGGGSIS GGGGTPGGGK SKGIIGSTQA NIGIVDSNIS PKESPDSIGD
2101: PQGRQTAVLV ESDGFVTKNG HRVVIHSRSP SITSRTADV