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| Accession Number: | P27732 |
| Protein Name: | CACNA1D aka CACNL1A2 aka CCHL1A2 aka CACH3 aka CACN4 |
| Length: | 2203 |
| Molecular Weight: | 250136.00 |
| Species: | Rattus norvegicus (Rat) [10116] |
| Number of TMSs: | 17 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | barium(2+), strontium(2+), calcium(2+) |
Cross database links:
| RefSeq: | NP_058994.1 |
|---|---|
| Entrez Gene ID: | 29716 |
| Pfam: | PF08763 PF00520 |
| KEGG: | rno:29716 |
Gene Ontology
GO:0016324
C:apical plasma membrane
GO:0005891
C:voltage-gated calcium channel complex
GO:0005509
F:calcium ion binding
GO:0005245
F:voltage-gated calcium channel activity
GO:0006816
P:calcium ion transport
GO:0019722
P:calcium-mediated signaling
GO:0007613
P:memory
GO:0055085
P:transmembrane transport
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References (8)[1] “Molecular diversity and functional characterization of voltage-dependent calcium channels (CACN4) expressed in pancreatic beta-cells.” Ihara Y.et.al. 7760845 [2] “Molecular cloning of multiple subtypes of a novel rat brain isoform of the alpha-1 subunit of the voltage-dependent calcium channel.” Hui A.et.al. 1648940 [3] “Transcriptional regulation of the neuronal L-type calcium channel alpha 1D subunit gene.” Kamp T.J.et.al. 7553731 [4] “Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney.” Yu A.S.L.et.al. 1279681 [5] “Multiple calcium channel transcripts in rat osteosarcoma cells: selective activation of alpha 1D isoform by parathyroid hormone.” Barry E.L.R.et.al. 7479909 [6] “Novel variants of voltage-operated calcium channel alpha-1 subunit transcripts in a rat liver-derived cell line: deletion in the IVS4 voltage sensing region.” Brereton H.M.et.al. 9232351 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MMMMMMMKKM QHQRQQQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA 61: RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 121: SIVDWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 181: IASGLLLHPN ASVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 241: AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 301: CFFADSDIVA EEDPAPCAFS GNGRQCAANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 361: ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG 421: DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 481: GEGETQGCCG SLWCWWKRRG AAKTGPSGCR RWGQAISKSK LRSHGAREAL CVCRCSLESL 541: VKLWTSRFSA HLQAAYVRPY SRRWRRWNRF NRRRCRAAVK SVTFYWLVIV LVFLNTLTIS 601: SEHYNQPDWL TQIQDIANKV LLALFTCEML VKMYSLGLQA YFVSLFNRFD CFVVCGGITE 661: TILVELELMS PLGVSVFRCV RLLRIFKVTR HWTSLSNLVA SLLNSMKSIA SLLLLLFLFI 721: IIFSLLGMQL FGGKFNFDET QTKRSTFDNF PQALLTVFQI LTGEDWNAVM YDGIMAYGGP 781: SSSGMIVCIY FIILFICGNY ILLKLFLAIA VDNLADAESL NTAQKEEAEE KERKKIARKE 841: SLENKKNNKP EVNQIANSDN KVTIDDYQEE AEDKDPYPPC DVPVGEEEEE EEEDEPEVPA 901: GPRPRRISEL NMKEKIAPIP EGSAFFILSK TNPIRVGCHK LINHHIFTNL ILVFIMLSSA 961: ALAAEDPIRS HSFRNTILGY FDYAFTAIFT VEILLKMTTF GAFLHKGAFC RNYFNLLDML 1021: VVGVSLVSFG IQSSAISVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA IRTIGNIMIV 1081: TTLLQFMFAC IGVQLFKGKF YRCTDEAKSN PEECRGLFIL YKDGDVDSPV VRERIWQNSD 1141: FNFDNVLSAM MALFTVSTFE GWPALLYKAI DSNGENVGPV YNYRVEISIF FIIYIIIVAF 1201: FMMNIFVGFV IVTFQEQGEK EYKNCELDKN QRQCVEYALK ARPLRRYIPK NPYQYKFWYV 1261: VNSSPFEYMM FVLIMLNTLC LAMQHYEQSK MFNDAMDILN MVFTGVFTVE MVLKVIAFKP 1321: KGYFSDAWNT FDSLIVIGSI IDVALSEADN SEESNRISIT FFRLFRVMRL VKLLSRGEGI 1381: RTLLWTFIKS FQALPYVALL IAMLFFIYAV IGMQMFGKVA MRDNNQINRN NNFQTFPQAV 1441: LLLFRCATGE AWQEIMLACL PGKLCDPDSD YNPGEEYTCG SNFAIVYFIS FYMLCAFLII 1501: NLFVAVIMDN FDYLTRDWSI LGPHHLDEFK RIWSEYDPEA KGRIKHLDVV TLLRRIQPPL 1561: GFGKLCPHRV ACKRLVAMNM PLNSDGTVMF NATLFALVRT ALKIKTEGNL EQANEELRAV 1621: IKKIWKKTSM KLLDQVVPPA GDDEVTVGKF YATFLIQDYF RKFKKRKEQG LVGKYPAKNT 1681: TIALQAGLRT LHDIGPEIRR AISCDLQDDE PEDSKPEEED VFKRNGALLG NYVNHVNSDR 1741: RESLQQTNTT HRPLHVQRPS IPPASDTEKP LFPPAGNSVC HNHHNHNSIG KQVPTSTNAN 1801: LNNANMSKAA HGKRPSIGDL EHVSENGHYS YKHDRELQRR SSIKRTRYYE TYIRSESGDE 1861: QLPTIFREDP EIHGYFRDPR CFGEQEYFSS EECCEDDSSP TWSRQNYSYY NRYPGSSMDF 1921: ERPRGYHHPQ GFLEDDDSPI GYDSRRSPRR RLLPPTPPSH RRSSFNFECL RRQNSQDDVL 1981: PSPALPHRAA LPLHLMQQQI MAVAGLDSSK AQKYSPSHST RSWATPPATP PYRDWTPCYT 2041: PLIQVDRSES MDQVNGSLPS LHRSSWYTDE PDISYRTFTP ASLTVPSSFR NKNSDKQRSA 2101: DSLVEAVLIS EGLGRYARDP KFVSATKHEI ADACDLTIDE MESAASTLLN GSVCPRANGD 2161: MGPISHRQDY ELQDFGPGYS DEEPDPGREE EDLADEMICI TTL