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1.A.1.11.12
T-type Ca2+ channel (CACNA1G; Cav3.1d), (σ1G T-type Ca2+ channel) in developing heart (fetal myocardium (Cribbs et al., 2001)) and elsewhere. Both Cav3.1 and Cav3.2 are permeated by divalent metal ions, such as Fe2+ and Mn2+, and possibly Cd2+ (Thévenod, 2010).  CaV3.1 channels are activated at low votage and regulate neuronal excitability in the spinal cord (Canto-Bustos et al. 2014).  It is regulated by protein kinase C (PKC) and the RanBPM protein (Q96S59) (Kim et al. 2009).  T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells, and support calcium signaling in secretory cells and vascular smooth muscle (Coutelier et al. 2015). The human ortholog is 85% identical to the mouse protein. These channels also determines the angiogenic potential of pulmonary microvascular endothelial cells (Zheng et al. 2019).  

Accession Number:Q9WUT2
Protein Name:Voltage-gated calcium channel, alpha-1-G subunit aka Cav3.1d
Length:2295
Molecular Weight:253960.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:16
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: Q9WUT2
RefSeq: NP_001106284.1    NP_033913.2   
Entrez Gene ID: 12291   
Pfam: PF00520   
KEGG: mmu:12291   

Gene Ontology

GO:0005891 C:voltage-gated calcium channel complex
GO:0005245 F:voltage-gated calcium channel activity
GO:0006816 P:calcium ion transport
GO:0060371 P:regulation of atrial cardiomyocyte membrane...
GO:0002027 P:regulation of heart rate
GO:0010045 P:response to nickel ion
GO:0055085 P:transmembrane transport

References (1)

[1] “A T-type calcium channel from mouse brain.”  Klugbauer N.et.al.   10087148

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MDEEEDGAGA EESGQPRSFT QLNDLSGAGG RQGPGSTEKD PGSADSEAEG LPYPALAPVV 
61:	FFYLSQDSRP RSWCLRTVCN PWFERVSMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 
121:	DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 
181:	TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 
241:	CFLPENFSLP LSVDLEPYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG EGGGGPPCGL 
301:	DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 
361:	YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 
421:	STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAVGV RAGLLSSPVA RGGQEPQPSG 
481:	SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRVPRASPE IQDRDANGSR WLMLPPPSTP 
541:	TPSGGPPRGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 
601:	MLKDKALVEV APSPGPPTLT TFNIPPGPFS SMHKLLETQS TGACHSSCKI SSPCSKADSG 
661:	ACGPDSCPYC ARTGAGEPES ADHEMPDSDS EAVYEFTQDA QHSDLRDPHR RRRPSLGPDA 
721:	EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 
781:	VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 
841:	VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 
901:	PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 
961:	AILVEGFQAE EIGKREDTSG QLSCIQLPVN SQGGDATKSE SEPDFFSPSV DGDGDRKKRL 
1021:	ALVALGEHSE LRKSLLPPLI IHTAATPMSL PKSSSTGVGE ALGSGSRRTS SSGSAEPGTA 
1081:	HHEMKSPPSA RSSPHSPWSA ASSWTSRRSS RNSLGRAPSL KRRSPSGERR SLLSGEGQES 
1141:	QDEEESSEED RASPAGSDHR HRGSLEREAK SSFDLPDTLQ VPGLHRTASG RSSASEHQDC 
1201:	NGKSASGRLA RTLRADDPPL DGDDGDDEGN LSKGERLRAW VRARLPACCR ERDSWSAYIF 
1261:	PPQSRFRLLC HRIITHKMFD HVVLVIIFLN CITIAMERPK IDPHSAERIF LTLSNYIFTA 
1321:	VFLAEMTVKV VALGWCFGEQ AYLRSSWNVL DGLLVLISVI DILVSMVSDS GTKILGMLRV 
1381:	LRLLRTLRPL RVISRAQGLK LVVETLMSSL KPIGNIVVIC CAFFIIFGIL GVQLFKGKFF 
1441:	VCQGEDTRNI TNKSDCAEAS YRWVRHKYNF DNLGQALMSL FVLASKDGWV DIMYDGLDAV 
1501:	GVDQQPIMNH NPWMLLYFIS FLLIVAFFVL NMFVGVVVEN FHKCRQHQEE EEARRREEKR 
1561:	LKRLEKKRRS KEKQMADLML DDVIASGSSA SAASEAQCKP YYSDYSRFRL LVHHLCTSHY 
1621:	LDLFITGVIG LNVVTMAMEH YQQPQILDEA LKICNYIFTV IFVLESVFKL VAFGFRRFFQ 
1681:	DRWNQLDLAI VLLSIMGITL EEIEVNASLP INPTIIRIMR VLRIARVLKL LKMAVGMRAL 
1741:	LDTVMQALPQ VGNLGLLFML LFFIFAALGV ELFGDLECDE THPCEGLGRH ATFRNFGMAF 
1801:	LTLFRVSTGD NWNGIMKDTL RDCDQESTCY NTVISPIYFV SFVLTAQFVL VNVVIAVLMK 
1861:	HLEESNKEAK EEAELEAELE LEMKTLSPQP HSPLGSPFLW PGVEGVNSPD SPKPGAPHTT 
1921:	AHIGAASSGF SLEHPTMVPH TEEGPVPLGP DLLTVRKSGV SRTHSLPNDS YMCRNGSTAE 
1981:	RSLGHRGWGL PKAQSGSILS VHSQPADTSC ILQLPKDAHY LLQPHGAPTW GAIPKLPPPG 
2041:	RSPLAQRPLR RQAAIRTDSL DVQGLGSRED LLSEVSGPSC PLTRSSSFWG GSSIQVQQRS 
2101:	GSQSKVSKHI RLPAPCPGLE PSWAKDPQET RSSLELDTEL SWISGDLLPS SQEEPLSPRD 
2161:	LKKCYSVEAQ SCRRRPGSWL DEQRRHSIAV SCLDSGSQPR LCPSPSSLGG QPLGGPGSRP 
2221:	KKKLSPPSIS IDPPESQGPR PPCSPGVCLR RRAPASDSKD PSASSPLDST AASPSPKKDA 
2281:	LSLSGLSSDP TDLDP