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1.A.1.11.13
Two-pore Ca2+ channel protein 1, TPC1 (Km(Ca2+))=50 µM; voltage gated; 461 aas; 12 TMSs) (Hashimoto et al., 2004; Kurusu et al, 2004; 2005). Each TPC subunit contains 12 TMSs that can be divided into two homologous copies of an S1-S6 Shaker-like 6-TMS domain. A functional TPC channel assembles as a dimer. The plant TPC channel is localized in the vacuolar membrane and is also called the SV channel for generating the slow vacuolar (SV) current. Three subfamilies of mammalian TPC channels have been defined - TPC1, 2, and 3 - with the first two being ubiquitously expressed in animals and TPC3 being expressed in some animals, but not in humans. Mammalian TPC1 and TPC2 are localized to endolysosomal membranes (She et al. 2022).

Accession Number:Q5QM84
Protein Name:Two pore calcium channel protein 1 aka TPC1
Length:757
Molecular Weight:87069.00
Species:Oryza sativa subsp. japonica (Rice) [39947]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate calcium(2+)

Cross database links:

RefSeq: NP_001043858.1   
Entrez Gene ID: 4325272   
Pfam: PF00520   
KEGG: osa:4325272   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005262 F:calcium channel activity
GO:0005509 F:calcium ion binding
GO:0005244 F:voltage-gated ion channel activity
GO:0006816 P:calcium ion transport
GO:0006952 P:defense response
GO:0055085 P:transmembrane transport

References (6)

[1] “Functional analysis of a rice putative voltage-dependent Ca2+ channel, OsTPC1, expressed in yeast cells lacking its homologous gene CCH1.”  Hashimoto K.et.al.   15111725
[2] “Identification of a putative voltage-gated Ca2+ -permeable channel (OsTPC1) involved in Ca2+ influx and regulation of growth and development in rice.”  Kurusu T.et.al.   15215504
[3] “The genome sequence and structure of rice chromosome 1.”  Sasaki T.et.al.   12447438
[4] “The map-based sequence of the rice genome.”  International rice genome sequencing project (IRGSP)et.al.   16100779
[5] “Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana.”  The rice annotation project (RAP)et.al.   17210932
[6] “Identification of a putative voltage-gated Ca2+ channel as a key regulator of elicitor-induced hypersensitive cell death and mitogen-activated protein kinase activation in rice.”  Kurusu T.et.al.   15941394

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRERGEMREA KAPLIAEAAE HISHSHGSGS SGTGSHTSGG GGGWRGSRQY QRRSDALAYG 
61:	NRYQKAAALV DLAEDGVGIP EDVLNDTRFE RAMRFYFVYL RLDWLWSLNL FALILLNFLE 
121:	KPLWCRGYSQ HACDQRDLYF LGQLPYLSKT ESLIYEGLTL VILVMDIFYP LSYEGLNLFW 
181:	KNTINKLKVL LLFILACDIL VFAFSPQPFR VAPYIRVAFL IMNIRELRMC AVTLVGMVGT 
241:	YLNVLALSLL FLLFASWLAY VTFEDTPQGK TVFSSYGTTL YQMFILFTTS NNPDVWVPAY 
301:	KSSRWSSLFF IVYVLLGVYF LTNLILAVIY DSFKEQLAKQ VSQADCTRKS ILEKAFGIID 
361:	ATGQGYLNKE QCLSLLDELN KYRSLPKTSR EDFELIFAEL DQSGDFKVTS EEFATLCNTI 
421:	AIKFQKEPPP SYLEKYPSFY HSALCEWLKS FVRSPLFEYI VIFVLLMNLV AVIIETTLDI 
481:	ENSSSQKVWQ EVEFVFGWIY VIEMALKIFS LGFGAYWMEG QNKFDFVLTW TIFIGETLTF 
541:	AFPSKLSFLS NGEWIRYLLL GRMLRLTRIL LQVRRFRAFV ATFFTLMSSL MPYLGIVFCT 
601:	LCIYCSLGLQ IFGGIVYAGN PTLEETDLFS NDYLLFNFND YPSGMVTLFN LLVMGNWQAW 
661:	MESYRQLTGS YWSLIYFVSF YLISVLLLLN LIVAFVLEAF FAEMELEKDG EADIQDPTLE 
721:	GRNRRRSVRV RTKGTMVDIL LHHMLSNELD GSQNRDQ