1.A.1.11.21
Voltage-gated L-type Ca2+ channel, Egl-19, isoform a. There are three isoforms encoded by the same gene, isoforms a, b and c, and all are expressed in all types of muscle (McDonald et al. 2023).
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| Accession Number: | G5EG02 |
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| Protein Name: | Protein EGL-19, isoform a |
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| Length: | 1783 |
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| Molecular Weight: | 202591.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 18 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
calcium(2+) |
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| Entrez Gene ID: |
177513
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| Pfam: |
PF08763
PF00520
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| KEGG: |
cel:C48A7.1
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GO:0005891
C:voltage-gated calcium channel complex
GO:0005245
F:voltage-gated calcium channel activity
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[1] “Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans.” Lee R.Y.N. et.al. 9321386
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.” The C. elegans sequencing consortium et.al. 9851916
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1: MSVLASMMSS GEDEEQAAAD EQERTDLWQQ TLQAAVAASS SQDATKKRPA QRKPLRQTNV
61: VERSERSLLC LSLNNPIRKL CISIVEWKPF EFLILFMICA NCIALAIYQP YPAQDSDYKN
121: TLLETIEYVF IVVFTIECVL KIVAMGFMFH PSAYLRNAWN ILDFIIVVIG LVSTILSKMS
181: IQGFDVKALR AFRVLRPLRL VSGVPSLQVV LNAILRAMIP LLHIALLVLF VILIYAIIGL
241: ELFCGKLHST CIDPATGQLA QKDPTPCGTD TEGSAFKCQP SDSLTNMGVR WECSSNTTWP
301: GPNNGITNFD NFGLAMLTVF QCVSLEGWTD VMYWVNDAVG REWPWIYFVT LVILGSFFVL
361: NLVLGVLSGE FSKEREKARA RGLFQKFREK QQLEEDLKGY LDWITQAEDI EPVNEDEQED
421: EPVAQTVVGE EADEEGEERV EDVRPSKWAA RMKRLEKLNR RCRRACRRLV KSQTFYWLVI
481: LLVLLNTLVL TSEHYGQSEW LDHFQTMANL FFVILFSMEM LLKMYSLGFT TYTTSQFNRF
541: DCFVVISSIL EFVLVYFDLM KPLGVSVLRS ARLLRIFKVT KYWTSLRNLV SSLLNSLRSI
601: ISLLLLLFLF IVIFALLGMQ VFGGKFNFNP QQPKPRANFD TFVQALLTVF QILTGEDWNT
661: VMYHGIESFG GVGTLGVIVC IYYIVLFICG NYILLNVFLA IAVDNLADAD SLTNAEKEEE
721: QQEIEGEDEE FEEGEDEGEE HGMDEPEGDE EMTSARPRRM SEVPAASTVK PIPKASSLFI
781: LSHTNSFRVF CNMVVNHSYF TNAVLFCILV SSAMLAAEDP LQANSTRNMI LNYFDYFFTS
841: VFTVEITLKV IVFGLVFHKG SFCRNAFNLL DILVVAVSLT SFVLRTDAMS VVKILRVLRV
901: LRPLRAINRA KGLKHVVQCV IVAVKTIGNI MLVTFMLQFM FAIIGVQLFK GTFFLCNDLS
961: KMTEAECRGE YIHYEDGDPT KPVSKKRVWS NNDFNFDNVG DAMISLFVVS TFEGWPQLLY
1021: VAIDSNEEDK GPIHNSRQAV ALFFIAFIIV IAFFMMNIFV GFVIVTFQNE GEREYENCEL
1081: DKNQRKCIEF ALKAKPHRRY IPRNRLQYRV WWFVTSRAFE YVIFLIIVMN TVSLACKHYP
1141: SSRGFEDFLD VFNLIFTGVF AFEAVLKIVA LNPKNYISDR WNVFDLLVVV GSFIDITYGK
1201: LNPGGTNLIS INFFRLFRVM RLVKLLSRGE GIRTLLWTFM KSFQALPYVA LLIVLLFFIY
1261: AVIGMQFFGK VALDDSTSIH RNNNFHSFPA AILVLFRSAT GEAWQDIMLS CSDREDVRCD
1321: PMSDDYHKGG LNESRCGNNF AYPYFISFFM LCSFLVINLF VAVIMDNFDY LTRDWSILGP
1381: HHLEEFVRLW SEYDPDAKGR IKHLDVVTLL RKISPPLGFG KLCPHRLACK RLVSMNMPLN
1441: SDGTVCFNAT LFALVRTNLK IYTEGNIDEA NEQLRSAIKR IWKRTHKDLL DEVVPPAGKE
1501: DDVTVGKFYA TFLIQDYFRR FKKRKEMEAK GVLPAQTPQA MALQAGLRTL HEIGPELKRA
1561: ISGNLETDFN FDEPEPQHRR PHSLFNNLVH RLSGAGSKSP TEHERIEKGS TLLPFQPRSF
1621: SPTHSLAGAE GSPVPSQMHR GAPINQSINL PPVNGSARRL PALPPYANHI HDETDDGPRY
1681: RDTGDRAGYD QSSRMVVANR KYADARIVGA ARREIEEAYS LGEQEIDLAA DSLAPLMQHV
1741: GMHDIRDINE NSRSALLRPA ENSSRQHDSR GGSQEDLLLV TTL