1.A.1.11.24
Voltage-sensitive calcium channel of 2693 aas (Docampo et al. 2013). Found to be essential for bloodstream-form Trypanosoma brucei through a genome-wide RNAi screen (Schmidt et al. 2018).
|
| Accession Number: | Q38BV7 |
|---|
| Protein Name: | Calcium channel protein, putative |
|---|
| Length: | 2693 |
|---|
| Molecular Weight: | 303776.00 |
|---|
| Species: | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) [999953] |
|---|
| Number of TMSs: | 24 |
|---|
| Substrate |
Ca2+ |
|---|
1: MAEPPPPQPL RKGFFRADPH GLRPPESPRD AEEPENHDIV EDPPLPSSRN LPPPRLRPMG
61: GGPPLAGAEA AATSHSNNRP SPGEVPPLPR PGTTTAVTSA QYNSLTPRQE LFSSPQTAVE
121: ENIPAGYDNQ MNVTSNDFSH SQDTGIKRIG DGATGSSAKT RSTIAHAPSG RFSEVVQERP
181: PIESVEQLCQ LQTLAHPVER FFVEYQPMAT RGCRSTQVPV EEDEALFNHL AEYTDDDSFF
241: SSGSAVLEED TRRLQNDPLR GRAIRSVFET LSLRSLTKGR IPYELEDQER SSAPWLKQVH
301: QRAIALHHSS FFIFPAGMKA RVIAYNILHH WLTEMLLMLI ILVYSMMTAA WSRDTWPTLE
361: KPSFMFFADV FFLCIYAIEF VARLFTSGAV SHSRAYFRSP WHCLDAAVLL LMILNCTNLQ
421: SMWNFSAFRL IRVLKSSTYV PIPINMKLLA KSLLRSTSNV VKVSTILFYV LLFFSLVGLQ
481: LFSGVLQHRC VSPTTKNVTN QLCRFNHSEK NESYYHGATC PSPHLCVADT YGNPHHGYRS
541: FDSVGHSFLS AFQIMTFQGW TSLLQETSDT TSVAAILYFF LAILICAWII PSLYLGVFIE
601: KIEKTRRLFV QKQLQLFDGM LLEQRQRLNE AIKLRDFVER DESGKLRRHP IELIRSASRR
661: IQRSKLSNSQ TSIATESESG EPAVVVKKPI GDTTKGRSRW TDEQRVQLHL SLTRQRDIAS
721: GGERRRRVVI KNDGEISGGT AGLHSQRKGS ESIGERAMMV TGDFALGGRV GVVQHHPLTH
781: TIGAAHGTDL PLAVRLDNEE EQLRFLKDYQ NPIDNDIMRR TNTFEDTNGN LHPSFVLTST
841: QRRGGSFDEA SNTIRTTTEA AGVIPSRHSA TLNGHNTSRM DSNGSLDEPT SKTQTVSKRG
901: SPMPRLSSGQ VPEVIIHDPE GGDFRFAETR SQKWGIVRNI LHMFTEGYPR IITQYIREHR
961: RMQRRFGLTP LNYVNKYEDD VLRKLRQRRV LQVKEPGAPS QTSRASGDEE LVEVNGNKVI
1021: LTDSDDIGDL SPIQMATNIV RNVPVTPFGA VMLVIVIVNG IFNATRYFQQ PEYWETALFV
1081: LGIIFTSFFV LEIVVRVIGL GLVSFLLDFN NLLDVTVTIL GFVELAYARS NVVTVLNWVR
1141: LLRLFRTLPF APMRRVSRVL LLGFADMLYA LFFFSIYMFM WILIGMSFFG GPNGMVDHTF
1201: QDYYTRGNFD TFSGASFAVS QAFSYTREEW VYLTWNGMQS RGEYTVLYFM AVVGVAFIAR
1261: YFFVAVFAWA WQSEEEEEEN YAAIAKGGSG GRREVTRLRW FDFTVWRSFK HIHGGFERRD
1321: VAPDEVFHLN EDMRKQLRIA EAKERFTKEA LAQTDLAMSQ RRMGSPMASP SATMGYNTDG
1381: YAPAAQVGTA PRYVNVGGQL QRHINPSVDF VDAQVPPLNA PISQFQAENA QLRFARRYST
1441: VPASVYTPVI QDDGIDRPSP SARSSPSDAG ERSGELGGES QQNGQEEGDG QYSPRGVSPN
1501: GTGGRATSTG LQRKSSVLGR FPRLGYDRAA GKKDGGSRSV SASAMQQTGD GNELRGDYVN
1561: EGEVNGGSMV YEHILYPGPR LRYKHVMRNQ YVRVFERCLD CNTYQQMPLR APPNVQQRTP
1621: EELHAEHCHM AAVRSSRQLV LNAIMGYVRL QKDINQPPTR DAVETVLGQA WSCGMLLFET
1681: IEYLSCSDIE QREYRTWDRT LEALQLQQWL IGLHVGEEQV GRATLAYTLA HRKREKLAVE
1741: HKSFELSWRQ RSFFFISPSN PVRRLSTRII QSRWFDIFIL TVIFIASFCL CFHIPGKAND
1801: PETGFVVLRA FDGIFTCIFL VEMIMKWISM GVILFRPEAY FWHWWNVFDF VIVIVSLIGL
1861: ADQHSALRSI KVLRCFRILI PMRVSNFNRS LSKISSALLD CLPTVANILL LFFINYFVWA
1921: VLAVRLLNGL THSCSDPSFV DITACEDAKH EWLPKVRNFD SFFQSLLTMI EVSVGSKWLD
1981: VIYTGVNGRT SEHAPMDDHY LARGFFFIVY YYVSHLILFS LFTASMIYSY LLTKNAAEGV
2041: LGITFEHQLW IRMQRMTLQL KPRVKLVPLC NHVSQFLHNV VIRPIFEVVG ASVLLLNILT
2101: MALHWYGETK SKASVLAAFQ YVWMFYFTVE AAMKIGAHGM RAFSRWAFSF DFFVLLLSFI
2161: GLIVDAASSE GMPFNVNVLR MLRLGRFFSA AKVFKPMRKQ FSLLHEVLIR SAVSLANVTL
2221: ILFLGVFVFT VLGLHLVGGV PVGEGGYFDD RYTNFNNFGN SLMMTFRLTT LENWSPSLRE
2281: GMNVTRKCTE DDCSVNYGSA FYCLLLLVFL GLIVLSFYMA VIVDHYVTAA RMNTSITRIE
2341: DLRRFRDLWS EFDPNGALVL HTHELPKLLE SLRPPLGLTS RHNRVELLRL LREYDIPNHR
2401: GKVHYHEVLL PLARRVLAMA FSRDTMDYRT TFDTLWRHSE KSLRALPTVL GKRSHATAAQ
2461: HFAASYVQAV CRRKKACREV QRVRSELWHE GRAVCDELGL PYADYGFGNL LLEGPDPMRD
2521: LVPRSASAAS SGGKGTRKGA SEAENAASSP LWRAGQAESP SSPRSEGETI DGRAPAARLP
2581: GAYQPAIEER EKRFGPDVPN ALRRHETRSE KLRRKDEERM LQSTPDDAVS SPVSNVRSNS
2641: QRVNVGEYQP PLGTDPTSWL GSNVNRGSTV GGPTTESRTS SVMPAPQGPT APE