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1.A.1.11.8
Voltage-dependent Ca2+ channel α-1A subunit (2212 aas), Cav2.1 (P/Q-type) (when mutated in humans, leads to a human channelopathy (episodic ataxia type-2 (EA2)) due to protein misfolding and retention in the E.R. (Mezghrani et al., 2008; Kleopa, 2011).  Mutations give rise to familial and sporadic hemiplegic migraine type 1 (FHM1, SHM1), episodic ataxia type 2 (EA2), and spinocerebellar ataxia type 6 (SCA6) (García Segarra et al. 2014).  Syntaxin 1A (Sx1A), SNAP-25 and synaptotagmin (Syt1), either alone or in combination, modify the kinetic properties of voltage-gated Ca2+ channels (VGCCs) including Cav2.1 (Cohen-Kutner et al. 2010).

Accession Number:P54282
Protein Name:Cav2.1
Length:2212
Molecular Weight:251527.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:18
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: P54282
DIP: DIP-29638N
RefSeq: NP_037050.2   
Entrez Gene ID: 25398   
Pfam: PF08763    PF00520   
KEGG: rno:25398   

Gene Ontology

GO:0043204 C:perikaryon
GO:0005891 C:voltage-gated calcium channel complex
GO:0005516 F:calmodulin binding
GO:0006816 P:calcium ion transport
GO:0007204 P:elevation of cytosolic calcium ion concentr...
GO:0055085 P:transmembrane transport

References (4)

[1] “Primary structure of a calcium channel that is highly expressed in the rat cerebellum.”  Starr T.V.B.et.al.   1648226
[2] “Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney.”  Yu A.S.L.et.al.   1279681
[3] “Rat brain expresses a heterogeneous family of calcium channels.”  Snutch T.P.et.al.   1692134
[4] “Differential modulation of Ca(v)2.1 channels by calmodulin and Ca2+-binding protein 1.”  Lee A.et.al.   11865310

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MARFGDEMPG RYGAGGGGSG PAAGVVVGAA GGRGAGGSRQ GGQPGAQRMY KQSMAQRART 
61:	MALYNPIPVR QNCLTVNRSL FLFSEDNVVR KYAKKITEWP PFEYMILATI IANCIVLALE 
121:	QHLPDDDKTP MSERLDDTEP YFIGIFCFEA GIKIVALGFA FHKGSYLRNG WNVMDFVVVL 
181:	TGILATVGTE FDLRTLRAVR VLRPLKLVSG IPSLQVVLKS IMKAMIPLLQ IGLLLFFAIL 
241:	IFAIIGLEFY MGKFHTTCFE EGTDDIQGES PAPCGTEEPA RTCPNGTKCQ PYWEGPNNGI 
301:	TQFDNILFAV LTVFQCITME GWTDLLYNSN DASGNTWNWL YFIPLIIIGS FFMLNLVLGV 
361:	LSGEFAKERE RVENRRAFLK LRRQQQIERE LNGYMEWISK AEEVILAEDE TDVEQRHPFD 
421:	GALRRATLKK SKTDLLNPEE AEDQLADIAS VGSPFARASI KSAKLENSTF FHKKERRMRF 
481:	YIRRMVKTQA FYWTVLSLVA LNTLWLAIVH YNQPEWLSDF LYYAEFIFLG LFMSEMFIKM 
541:	YGLGTRPYFH SSFNCFDCGV IIGSIFEVIW AVIKPGTSFG ISVLRALRLL RIFKVTKYWA 
601:	SLRNLVVSLL NSMKSIISLL FLLFLFIVVF ALLGMQLFGG QFNFDEGTPP TNFDTFPAAI 
661:	MTVFQILTGE DWNEVMYDEI KSQGGVQGGM VFSIYFIVLT LFGNYTLLNV FLAIAVDNLA 
721:	NAQELTKDEQ EEEEAANQKL ALQKAKEVAE VSPLSAANMS IAVKEQQKNQ KPAKSVWEQR 
781:	TSEMRKQNLL ASREALYGDA AERWPTTYAR PLRPDVKTHL DRPLVVDPQE NRNNNTNKSR 
841:	APEALRQTAR PRESARDPDA RRAWPSSPER APGREGPYGR ESEPQQREHA PPREHVPWDA 
901:	DPERAKAGDA PRRHTHRPVA EGEPRRHRAR RRPGDEPDDR PERRPRPRDA TRPARAADGE 
961:	GDDGERKRRH RHGPPAHDDR ERRHRRRKES QGSGVPMSGP NLSTTRPIQQ DLGRQDLPLA 
1021:	EDLDNMKNNK LATGEPASPH DSLGHSGLPP SPAKIGNSTN PGPALATNPQ NAASRRTPNN 
1081:	PGNPSNPGPP KTPENSLIVT NPSSTQPNSA KTARKPEHMA VEIPPACPPL NHTVVQVNKN 
1141:	ANPDPLPKKE EEKKEEEEAD PGEDGPKPMP PYSSMFILST TNPLRRLCHY ILNLRYFEMC 
1201:	ILMVIAMSSI ALAAEDPVQP NAPRNNVLRY FDYVFTGVFT FEMVIKMIDL GLVLHQGAYF 
1261:	RDLWNILDFI VVSGALVAFA FTGNSKGKDI NTIKSLRVLR VLRPLKTIKR LPKLKAVFDC 
1321:	VVNSLKNVFN ILIVYMLFMF IFAVVAVQLF KGKFFHCTDE SKEFERDCRG KYLLYEKNEV 
1381:	KARDREWKKY DFHYDNVLWA LLTLFTVSTG EGWPQVLKHS VDATFENQGP SPGYRMEMSI 
1441:	FYVVYFVVFP FFFVNIFVAL IIITFQEQGD KMMEEYSLEK NERACIDFAI SAKPLTRHMP 
1501:	QNKQSFQYRM WQFVVSPPFE YTIMAMIALN TIVLMMKFYG ASVAYENALR VFNIVFTSLF 
1561:	SLECVLKVMA FGILNYFRDA WNIFDFVTVL GSITDILVTE FGNNFINLSF LRLFRAARLI 
1621:	KLLRQGYTIR ILLWTFVQSF KALPYVCLLI AMLFFIYAII GMQVFGNIGI DGEDEDSDED 
1681:	EFQITEHNNF RTFFQALMLL FRSATGEAWH NIMLSCLSGK PCDKNSGIQK PECGNEFAYF 
1741:	YFVSFIFLCS FLMLNLFVAV IMDNFEYLTR DSSILGPHHL DEYVRVWAEY DPAACGRIHY 
1801:	KDMYSLLRVI SPPLGLGKKC PHRVACKRLL RMDLPVADDN TVHFNSTLMA LIRTALDIKI 
1861:	AKGGADKQQM DAELRKEMMA IWPNLSQKTL DLLVTPHKST DLTVGKIYAA MMIMEYYRQS 
1921:	KAKKLQAMRE EQNRTPLMFQ RMEPPSPTQE GGPSQNALPS TQLDPGGGLM AQESSMKESP 
1981:	SWVTQRAQEM FQKTGTWSPE RGPPIDMPNS QPNSQSVEMR EMGTDGYSDS EHYLPMEGQT 
2041:	RAASMPRLPA ENQRRRGRPR GNNLSTISDT SPMKRSASVL GPKARRLDDY SLERVPPEEN 
2101:	QRYHQRRRDR GHRTSERSLG RYTDVDTGLG TDLSMTTQSG DLPSKDRDQD RGRPKDRKHR 
2161:	PHHHHHHHHH HPPAPDRERY AQERPDTGRA RAREQRWSRS PSEGREHATH RQ