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1.A.1.14.5
Voltage-gated Na+ channel, NavCh or NavAb. The 3d-structure is known (3ROW; Payandeh et al., 2011; 4MW3A-D; 4+ selectivity through partial dehydration of Na+ via its direct interaction with conserved glutamate side chains). The pore is preferentially occupied by two ions, which can switch between different configurations by crossing low free-energy barriers (Furini and Domene, 2012). Jiang et al. 2018 presented high-resolution structures of NavAb with the analogous gating-charge mutations that have similar functional effects as in the human channels that cause hypokalaemic and normokalaemic periodic paralysis.  Wisedchaisri et al. 2019 presented a cryo-EM structure of the resting state and a complete voltage-dependent gating mechanism via the voltage sensor (VS). The S4 segment of the VS is drawn intracellularly, with three gating charges passing through the transmembrane electric field. This movement forms an elbow connecting S4 to the S4-S5 linker, tightens the collar around the S6 activation gate, and prevents its opening. This structure supports the classical "sliding helix" mechanism of voltage sensing and provides a complete gating mechanism for voltage sensor function, pore opening, and activation-gate closure based on high-resolution structures of a single sodium channel protein (Wisedchaisri et al. 2019). (see also TC#s 1.A.1.10.4 and 1.A.1.11.32). The transport reaction catalyzed by NavCh is: Na+ (in) ⇌ Na+ (out)

Accession Number:A8EVM5
Protein Name:Ion transport protein
Length:267
Molecular Weight:31071.00
Species:Arcobacter butzleri (strain RM4018) [367737]
Number of TMSs:5
Substrate Na+

Cross database links:

DIP: DIP-59168N
Entrez Gene ID: 5624115   
Pfam: PF00520   
KEGG: abu:Abu_1752   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005216 F:ion channel activity

References (2)

[1] “The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri.”  Miller W.G.et.al.   18159241
[2] “The crystal structure of a voltage-gated sodium channel.”  Payandeh J.et.al.   21743477
Structure:
3RVY   3RVZ   3RW0   4EKW   4MS2   4MTF   4MTG   4MTO   4MVM   4MVO   [...more]

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MYLRITNIVE SSFFTKFIIY LIVLNGITMG LETSKTFMQS FGVYTTLFNQ IVITIFTIEI 
61:	ILRIYVHRIS FFKDPWSLFD FFVVAISLVP TSSGFEILRV LRVLRLFRLV TAVPQMRKIV 
121:	SALISVIPGM LSVIALMTLF FYIFAIMATQ LFGERFPEWF GTLGESFYTL FQVMTLESWS 
181:	MGIVRPLMEV YPYAWVFFIP FIFVVTFVMI NLVVAIIVDA MAILNQKEEQ HIIDEVQSHE 
241:	DNINNEIIKL REEIVELKEL IKTSLKN