1.A.1.14.8 Voltage-gated Na+ channel, Nsv, of 277 aas and 6 TMSs with a structually defined C-terminal regulatory domain (Miller et al. 2016). Voltage-gated sodium channels (NaVs) are activated by
transiting the voltage sensor from the deactivated to the activated
state. Tang et al. 2017 identified peptide toxins stabilizing the deactivated
VSM of bacterial NaVs. A cystine knot toxin, called JZTx-27, from the venom of the tarantula Chilobrachys jingzhao proved to be a high-affinity antagonist. JZTx-27 stabilizes the inactive form of the voltage sensor, thereby inhibiting channel activity (Tang et al. 2017).
|
Accession Number: | J8TM36 |
Protein Name: | Potassium ion channel transporter |
Length: | 277 |
Molecular Weight: | 31949.00 |
Species: | Bacillus alcalophilus ATCC 27647 = CGMCC 1.3604 [1218173] |
Number of TMSs: | 5 |
Substrate |
sodium(1+) |
---|
1: MQKQSLLIHF SKKIVSHRYF TRIIITLILF NALLVGLETY PALRHEYGSL FHVLDVILLW
61: IFTLEILTRF LATTPKKDFF KGGWNWFDTI IVLSSHIFVG GHFITVLRIL RVLRVLRAIS
121: VIPSLRRLVD ALMLTIPALG NILILMSIIF YIFAVLGTML FANVAPEYFA NLQLSMLTLF
181: QIVTLDSWGS GVMRPILVDI PWAWTYFIAF VLVGTFIIFN LFIGVIVNNV EKANEDEVKD
241: KVKEKEEAAQ KQMDSLHEEL KEIKQYLKSI EKQNRSS