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1.A.1.16.3
Small conductance calcium-gated potassium (SK) channel. Three charged residues in TMS S6 of SK channels near the inner mouth of the pore collectively control the conductance and rectification through an electrostatic mechanism (Li and Aldrich, 2011). The SK channel inhibitors NS8593 and UCL1684 prevent the development of atrial fibrillation via atrial-selective inhibition of sodium channel activity (Burashnikov et al. 2020).

Accession Number:Q7KVW5
Protein Name:Small conductance calcium-activated potassium channel protein - Drosophila melanogaster (Fruit fly).
Length:924
Molecular Weight:101444.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

eggNOG: inNOG09080
RefSeq: NP_001096885.2    NP_525078.3    NP_726986.3    NP_726987.2    NP_726988.3    NP_726989.3    NP_996354.2   
Entrez Gene ID: 31456   
Pfam: PF02888    PF07885    PF03530   
KEGG: dme:Dmel_CG1070   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005516 F:calmodulin binding
GO:0016286 F:small conductance calcium-activated potassi...
GO:0006813 P:potassium ion transport

References (4)

[1] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[2] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[3] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569
[4] “RNA editing in Drosophila melanogaster: new targets and functional consequences.”  Stapleton M.et.al.   17018572

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MSIQKLNDTT NSGYVSSEET DSLLVSSSNP SKGGGRTALL RQVKSNSTNG PTTGASTSSS 
61:	GSVSGGGGGS GSGGGSASGS AAGASKPTLM RQDRTSTYLT SPQQSQHARM GSEESMRGGA 
121:	SGAAGHDEDV EQGLVRSSIV PDIEVHEEDQ EQHSQQLNAT TMATMTNNQQ QQQPTISIMN 
181:	LSLKPGDSHS HSSSPGSHPN LGTSSYQNLA SSIPPSVPSR CRACRNCSRR ASTTPTTLID 
241:	RSASRDSVKS AFQQGNLSGS MAICISNSAL PQQQQLQQQY HLQQQQQQHY QLQQHHLHQQ 
301:	QLQQSQQQVP PVLITSSPTN GSRIIRQSSQ PESSSTAICC GPHSACVGHA HSHSHTVPNV 
361:	SLKQLRESSG DGIAGIAADS LRINGGMRPF KQLRKPASTL SIPGSMKTPS IANREQISSG 
421:	CNEEAAEALV GIHSDYPRYM EERALTGGNT SRKPSTNSAK HKPNVGYRLG KRKALFEKRK 
481:	RISDYALVMG MFGIIVMVIE NELSSAGVYT KASFYSTALK TLISVSTVIL LGLIVAYHAL 
541:	EVQLFMIDNC ADDWRIAMTW QRISQIGLEL FICAIHPIPG EYYFQWTTKL ANKNKTIGTE 
601:	MVPYDVALSL PMFLRLYLIC RVMLLHSKLF TDASSRSIGA LNRINFNTRF VLKTLMTICP 
661:	GTVLLVFMVS LWIIASWTLR QCERFHDEEH ANLLNSMWLT AITFLCVGYG DIVPNTYCGR 
721:	GITLTCGMVG AGCTALLVAV VSRKLELTRA EKHVHNFMMD TQLTKRLKNA AANVLRETWL 
781:	IYKHTRLVKR VNPGRVRTHQ RKFLLAIYAL RKVKMDQRKL MDNANTITDM AKTQNTVYEI 
841:	ISDMSSRQDA IEERLTNLED KMQSIQEHME SLPDLLSRCL TQHQERIEQR RNFLHPDTAA 
901:	VAPIQAPTPQ SMFNAAPMLF PHSS