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1.A.1.16.7
Small conductance calcium-activated potassium channel protein 3 of 736 aas and 6 TMSs, SK3 or KCNN3. It forms a voltage-independent potassium channel, activated by intracellular calcium (Bauer et al. 2019). Activation is followed by membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic after-hyperpolarization. The channel is blocked by apamin. Contrary to its bradycardic effect in the sinus node, blockage of its current by apamin accelerates ventricular automaticity and causes repeated, nonsustained, ventricular tachycardia in normal ventricles. Ryanodine receptor 2 blockage reversed the apamin effects on ventricular automaticity (Wan et al. 2019).

Accession Number:Q9UGI6
Protein Name:Small conductance calcium-activated potassium channel protein 3
Length:736
Molecular Weight:82026.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

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FASTA formatted sequence
1:	MDTSGHFHDS GVGDLDEDPK CPCPSSGDEQ QQQQQQQQQQ QPPPPAPPAA PQQPLGPSLQ 
61:	PQPPQLQQQQ QQQQQQQQQQ QQQQQPPHPL SQLAQLQSQP VHPGLLHSSP TAFRAPPSSN 
121:	STAILHPSSR QGSQLNLNDH LLGHSPSSTA TSGPGGGSRH RQASPLVHRR DSNPFTEIAM 
181:	SSCKYSGGVM KPLSRLSASR RNLIEAETEG QPLQLFSPSN PPEIVISSRE DNHAHQTLLH 
241:	HPNATHNHQH AGTTASSTTF PKANKRKNQN IGYKLGHRRA LFEKRKRLSD YALIFGMFGI 
301:	VVMVIETELS WGLYSKDSMF SLALKCLISL STIILLGLII AYHTREVQLF VIDNGADDWR 
361:	IAMTYERILY ISLEMLVCAI HPIPGEYKFF WTARLAFSYT PSRAEADVDI ILSIPMFLRL 
421:	YLIARVMLLH SKLFTDASSR SIGALNKINF NTRFVMKTLM TICPGTVLLV FSISLWIIAA 
481:	WTVRVCERYH DQQDVTSNFL GAMWLISITF LSIGYGDMVP HTYCGKGVCL LTGIMGAGCT 
541:	ALVVAVVARK LELTKAEKHV HNFMMDTQLT KRIKNAAANV LRETWLIYKH TKLLKKIDHA 
601:	KVRKHQRKFL QAIHQLRSVK MEQRKLSDQA NTLVDLSKMQ NVMYDLITEL NDRSEDLEKQ 
661:	IGSLESKLEH LTASFNSLPL LIADTLRQQQ QQLLSAIIEA RGVSVAVGTT HTPISDSPIG 
721:	VSSTSFPTPY TSSSSC