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Accession Number: | Q6VV64 |
Protein Name: | TRESK-1 |
Length: | 394 |
Molecular Weight: | 44403.00 |
Species: | Mus musculus (Mouse) [10090] |
Number of TMSs: | 6 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | potassium(1+) |
Cross database links:
RefSeq: | NP_997144.1 |
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Entrez Gene ID: | 332396 |
Pfam: | PF07885 |
KEGG: | mmu:332396 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0015269
F:calcium-activated potassium channel activity
GO:0006813
P:potassium ion transport
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References (5)[1] “The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin.” Czirjak G.et.al. 14981085 [2] “Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK.” Keshavaprasad B.et.al. 16192517 [3] “The transcriptional landscape of the mammalian genome.” Carninci P.et.al. 16141072 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK.” Czirjak G.et.al. 16569637
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External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MEAEEPPEAR RCCPEALGKA RGCCPEALGK LLPGLCFLCC LVTYALVGAA LFSAVEGRPD 61: PEAEENPELK KFLDDLCNIL KCNLTVVEGS RKNLCEHLQH LKPQWLKAPQ DWSFLSALFF 121: CCTVFSTVGY GHMYPVTRLG KFLCMLYALF GIPLMFLVLT DIGDILATIL SRAYSRFQAL 181: LCLPHDIFKW RSLPLCRKQP DSKPVEEAIP QIVIDAGVDE LLNPQPSKDP PSPSCNVELF 241: ERLVAREKKN KLQPPTRPVE RSNSCPELVL GRLSCSILSN LDEVGQQVER LDIPLPVIAL 301: VVFAYISCAA AILPFWETEL GFEDAFYFCF VTLTTIGFGD IVLVHPHFFL FFSIYIIVGM 361: EILFIAFKLM QNRLLHTYKT LMLFVCQREV SLPW